Gene name: SLC9B2

Uniprot entry:

Q86UD5

Protein names:

Sodium/hydrogen exchanger 9B2 (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2)

Protein sequence:

1_MGDED 6_ KRITY 11_ EDSEP 16_ STGMN 21_ YTPSM 26_ HQEAQ 31_ EETVM 36_ KLKGI 41_ DANEP 46_ TEGSI 51_ LLKSS 56_ EKKLQ 61_ ETPTE 66_ ANHVQ 71_ RLRQM 76_ LACPP 81_ HGLLD 86_ RVITN 91_ VTIIV 96_ LLWAV 101_ VWSIT 106_ GSECL 111_ PGGNL 116_ FGIII 121_ LFYCA 126_ IIGGK 131_ LLGLI 136_ KLPTL 141_ PPLPS 146_ LLGML 151_ LAGFL 156_ IRNIP 161_ VINDN 166_ VQIKH 171_ KWSSS 176_ LRSIA 181_ LSIIL 186_ VRAGL 191_ GLDSK 196_ ALKKL 201_ KGVCV 206_ RLSMG 211_ PCIVE 216_ ACTSA 221_ LLAHY 226_ LLGLP 231_ WQWGF 236_ ILGFV 241_ LGAVS 246_ PAVVV 251_ PSMLL 256_ LQGGG 261_ YGVEK 266_ GVPTL 271_ LMAAG 276_ SFDDI 281_ LAITG 286_ FNTCL 291_ GIAFS 296_ TGSTV 301_ FNVLR 306_ GVLEV 311_ VIGVA 316_ TGSVL 321_ GFFIQ 326_ YFPSR 331_ DQDKL 336_ VCKRT 341_ FLVLG 346_ LSVLA 351_ VFSSV 356_ HFGFP 361_ GSGGL 366_ CTLVM 371_ AFLAG 376_ MGWTS 381_ EKAEV 386_ EKIIA 391_ VAWDI 396_ FQPLL 401_ FGLIG 406_ AEVSI 411_ ASLRP 416_ ETVGL 421_ CVATV 426_ GIAVL 431_ IRILT 436_ TFLMV 441_ CFAGF 446_ NLKEK 451_ IFISF 456_ AWLPK 461_ ATVQA 466_ AIGSV 471_ ALDTA 476_ RSHGE 481_ KQLED 486_ YGMDV 491_ LTVAF 496_ LSILI 501_ TAPIG 506_ SLLIG 511_ LLGPR 516_ LLQKV 521_ EHQNK 526_ DEEVQ 531_GETSV

Protein annotations

Protein functions:

1: Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:18508966, PubMed:22948142, PubMed:28154142, PubMed:36177733). Uses the proton gradient/membrane potential to extrude sodium (PubMed:22948142). Contributes to the regulation of intracellular pH and sodium homeostasis (By similarity). Also able to mediate Na(+)/Li(+) antiporter activity in kidney (PubMed:22948142). May play a physiological role in renal tubular function and blood pressure homeostasis (By similarity). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity)