Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)
1_MAARS 6_ WQDEL 11_ AQQAE 16_ EGSAR 21_ LREML 26_ SVGLG 31_ FLRTE 36_ LGLDL 41_ GLEPK 46_ RYPGW 51_ VILVG 56_ TGALG 61_ LLLLF 66_ LLGYG 71_ WAAAC 76_ AGARK 81_ KRRSP 86_ PRKRE 91_ EAAAV 96_ PAAAP 101_ DDLAL 106_ LKNLR 111_ SEEQK 116_ KKNRK 121_ KLSEK 126_ PKPNG 131_ RTVEV 136_ AEGEA 141_ VRTPQ 146_ SVTAK 151_ QPPEI 156_ DKKNE 161_ KSKKN 166_ KKKSK 171_ SDAKA 176_ VQNSS 181_ RHDGK 186_ EVDEG 191_ AWETK 196_ ISHRE 201_ KRQQR 206_ KRDKV 211_ LTDSG 216_ SLDST 221_ IPGIE 226_ NTITV 231_ TTEQL 236_ TTASF 241_ PVGSK 246_ KNKGD 251_ SHLNV 256_ QVSNF 261_ KSGKG 266_ DSTLQ 271_ VSSGL 276_ NENLT 281_ VNGGG 286_ WNEKS 291_ VKLSS 296_ QISAG 301_ EEKWN 306_ SVSPA 311_ SAGKR 316_ KTEPS 321_ AWSQD 326_ TGDAN 331_ TNGKD 336_ WGRSW 341_ SDRSI 346_ FSGIG 351_ STAEP 356_ VSQST 361_ TSDYQ 366_ WDVSR 371_ NQPYI 376_ DDEWS 381_ GLNGL 386_ SSADP 391_ NSDWN 396_ APAEE 401_ WGNWV 406_ DEERA 411_ SLLKS 416_ QEPIP 421_ DDQKV 426_ SDDDK 431_ EKGEG 436_ ALPTG 441_ KSKKK 446_ KKKKK 451_ KQGED 456_ NSTAQ 461_ DTEEL 466_ EKEIR 471_ EDLPV 476_ NTSKT 481_ RPKQE 486_ KAFSL 491_ KTIST 496_ SDPAE 501_ VLVKN 506_ SQPIK 511_ TLPPA 516_ TSTEP 521_ SVILS 526_ KSDSD 531_ KSSSQ 536_ VPPIL 541_ QETDK 546_ SKSNT 551_ KQNSV 556_ PPSQT 561_ KSETS 566_ WESPK 571_ QIKKK 576_KKARR
1: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance