Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2)
1_MMEEL 6_ HSLDP 11_ RRQEL 16_ LEARF 21_ TGVGV 26_ SKGPL 31_ NSESS 36_ NQSLC 41_ SVGSL 46_ SDKEV 51_ ETPEK 56_ KQNDQ 61_ RNRKR 66_ KAEPY 71_ ETSQG 76_ KGTPR 81_ GHKIS 86_ DYFEF 91_ AGGSA 96_ PGTSP 101_ GRSVP 106_ PVARS 111_ SPQHS 116_ LSNPL 121_ PRRVE 126_ QPLYG 131_ LDGSA 136_ AKEAT 141_ EEQSA 146_ LPTLM 151_ SVMLA 156_ KPRLD 161_ TEQLA 166_ QRGAG 171_ LCFTF 176_ VSAQQ 181_ NSPSS 186_ TGSGN 191_ TEHSC 196_ SSQKQ 201_ ISIQH 206_ RQTQS 211_ DLTIE 216_ KISAL 221_ ENSKN 226_ SDLEK 231_ KEGRI 236_ DDLLR 241_ ANCDL 246_ RRQID 251_ EQQKM 256_ LEKYK 261_ ERLNR 266_ CVTMS 271_ KKLLI 276_ EKSKQ 281_ EKMAC 286_ RDKSM 291_ QDRLR 296_ LGHFT 301_ TVRHG 306_ ASFTE 311_ QWTDG 316_ YAFQN 321_ LIKQQ 326_ ERINS 331_ QREEI 336_ ERQRK 341_ MLAKR 346_ KPPAM 351_ GQAPP 356_ ATNEQ 361_ KQRKS 366_ KTNGA 371_ ENETP 376_ SSGNT 381_ ELKDT 386_ APALG 391_ AHSLL 396_ RLTLA 401_ EYHEQ 406_ EEIFK 411_ LRLGH 416_ LKKEE 421_ AEIQA 426_ ELERL 431_ ERVRN 436_ LHIRE 441_ LKRIH 446_ NEDNS 451_ QFKDH 456_ PTLND 461_ RYLLL 466_ HLLGR 471_ GGFSE 476_ VYKAF 481_ DLTEQ 486_ RYVAV 491_ KIHQL 496_ NKNWR 501_ DEKKE 506_ NYHKH 511_ ACREY 516_ RIHKE 521_ LDHPR 526_ IVKLY 531_ DYFSL 536_ DTDSF 541_ CTVLE 546_ YCEGN 551_ DLDFY 556_ LKQHK 561_ LMSEK 566_ EARSI 571_ IMQIV 576_ NALKY 581_ LNEIK 586_ PPIIH 591_ YDLKP 596_ GNILL 601_ VNGTA 606_ CGEIK 611_ ITDFG 616_ LSKIM 621_ DDDSY 626_ NSVDG 631_ MELTS 636_ QGAGT 641_ YWYLP 646_ PECFV 651_ VGKEP 656_ PKISN 661_ KVDVW 666_ SVGVI 671_ FYQCL 676_ YGRKP 681_ FGHNQ 686_ SQQDI 691_ LQENT 696_ ILKAT 701_ EVQFP 706_ PKPVV 711_ TPEAK 716_ AFIRR 721_ CLAYR 726_ KEDRI 731_ DVQQL 736_ ACDPY 741_ LLPHI 746_ RKSVS 751_ TSSPA 756_ GAAIA 761_ STSGA 766_SNNSS
1: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037)