Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)
1_MARRP 6_ RAPAA 11_ SGEEF 16_ SFVSP 21_ LVKYL 26_ LFFFN 31_ MLFWV 36_ ISMVM 41_ VAVGV 46_ YARLM 51_ KHAEA 56_ ALACL 61_ AVDPA 66_ ILLIV 71_ VGVLM 76_ FLLTF 81_ CGCIG 86_ SLREN 91_ ICLLQ 96_ TFSLC 101_ LTAVF 106_ LLQLA 111_ AGILG 116_ FVFSD 121_ KARGK 126_ VSEII 131_ NNAIV 136_ HYRDD 141_ LDLQN 146_ LIDFG 151_ QKKFS 156_ CCGGI 161_ SYKDW 166_ SQNMY 171_ FNCSE 176_ DNPSR 181_ ERCSV 186_ PYSCC 191_ LPTPD 196_ QAVIN 201_ TMCGQ 206_ GMQAF 211_ DYLEA 216_ SKVIY 221_ TNGCI 226_ DKLVN 231_ WIHSN 236_ LFLLG 241_ GVALG 246_ LAIPQ 251_ LVGIL 256_ LSQIL 261_ VNQIK 266_ DQIKL 271_ QLYNQ 276_QHRAD
1: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:30463011, PubMed:37516108). Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011)