Glucosylceramide transporter ABCA12 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 12) (ATP-binding cassette transporter 12) (ATP-binding cassette 12)
1_MASLF 6_ HQLQI 11_ LVWKN 16_ WLGVK 21_ RQPLW 26_ TLVLI 31_ LWPVI 36_ IFIIL 41_ AITRT 46_ KFPPT 51_ AKPTC 56_ YLAPR 61_ NLPST 66_ GFFPF 71_ LQTLL 76_ CDTDS 81_ KCKDT 86_ PYGPQ 91_ DLLRR 96_ KGIDD 101_ ALFKD 106_ SEILR 111_ KSSNL 116_ DKDSS 121_ LSFQS 126_ TQVPE 131_ RRHAS 136_ LATVF 141_ PSPSS 146_ DLEIP 151_ GTYTF 156_ NGSQV 161_ LARIL 166_ GLEKL 171_ LKQNS 176_ TSEDI 181_ RRELC 186_ DSYSG 191_ YIVDD 196_ AFSWT 201_ FLGRN 206_ VFNKF 211_ CLSNM 216_ TLLES 221_ SLQEL 226_ NKQFS 231_ QLSSD 236_ PNNQK 241_ IVFQE 246_ IVRML 251_ SFFSQ 256_ VQEQK 261_ AVWQL 266_ LSSFP 271_ NVFQN 276_ DTSLS 281_ NLFDV 286_ LRKAN 291_ SVLLV 296_ VQKVY 301_ PRFAT 306_ NEGFR 311_ TLQKS 316_ VKHLL 321_ YTLDS 326_ PAQGD 331_ SDNIT 336_ HVWNE 341_ DDGQT 346_ LSPSS 351_ LAAQL 356_ LILEN 361_ FEDAL 366_ LNISA 371_ NSPYI 376_ PYLAC 381_ VRNVT 386_ DSLAR 391_ GSPEN 396_ LRLLQ 401_ STIRF 406_ KKSFL 411_ RNGSY 416_ EDYFP 421_ PVPEV 426_ LKSKL 431_ SQLRN 436_ LTELL 441_ CESET 446_ FSLIE 451_ KSCQL 456_ SDMSF 461_ GSLCE 466_ ESEFD 471_ LQLLE 476_ AAELG 481_ TEIAA 486_ SLLYH 491_ DNVIS 496_ KKVRD 501_ LLTGD 506_ PSKIN 511_ LNMDQ 516_ FLEQA 521_ LQMNY 526_ LENIT 531_ QLIPI 536_ IEAML 541_ HVNNS 546_ ADASE 551_ KPGQL 556_ LEMFK 561_ NVEEL 566_ KEDLR 571_ RTTGM 576_ SNRTI 581_ DKLLA 586_ IPIPD 591_ NRAEI 596_ ISQVF 601_ WLHSC 606_ DTNIT 611_ TPKLE 616_ DAMKE 621_ FCNLS 626_ LSERS 631_ RQSYL 636_ IGLTL 641_ LHYLN 646_ IYNFT 651_ YKVFF 656_ PRKDQ 661_ KPVEK 666_ MMELF 671_ IRLKE 676_ ILNQM 681_ ASGTH 686_ PLLDK 691_ MRSLK 696_ QMHLP 701_ RSVPL 706_ TQAMY 711_ RSNRM 716_ NTPQG 721_ SFSTI 726_ SQALC 731_ SQGIT 736_ TEYLT 741_ AMLPS 746_ SQRPK 751_ GNHTK 756_ DFLTY 761_ KLTKE 766_ QIASK 771_ YGIPI 776_ NSTPF 781_ CFSLY 786_ KDIIN 791_ MPAGP 796_ VIWAF 801_ LKPML 806_ LGRIL 811_ YAPYN 816_ PVTKA 821_ IMEKS 826_ NVTLR 831_ QLAEL 836_ REKSQ 841_ EWMDK 846_ SPLFM 851_ NSFHL 856_ LNQAI 861_ PMLQN 866_ TLRNP 871_ FVQVF 876_ VKFSV 881_ GLDAV 886_ ELLKQ 891_ IDELD 896_ ILRLK 901_ LENNI 906_ DIIDQ 911_ LNTLS 916_ SLTVN 921_ ISSCV 926_ LYDRI 931_ QAAKT 936_ IDEME 941_ REAKR 946_ LYKSN 951_ ELFGS 956_ VIFKL 961_ PSNRS 966_ WHRGY 971_ DSGNV 976_ FLPPV 981_ IKYTI 986_ RMSLK 991_ TAQTT 996_ RSLRT 1001_ KIWAP 1006_ GPHNS 1011_ PSHNQ 1016_ IYGRA 1021_ FIYLQ 1026_ DSIER 1031_ AIIEL 1036_ QTGRN 1041_ SQEIA 1046_ VQVQA 1051_ IPYPC 1056_ FMKDN 1061_ FLTSV 1066_ SYSLP 1071_ IVLMV 1076_ AWVVF 1081_ IAAFV 1086_ KKLVY 1091_ EKDLR 1096_ LHEYM 1101_ KMMGV 1106_ NSCSH 1111_ FFAWL 1116_ IESVG 1121_ FLLVT 1126_ IVILI 1131_ IILKF 1136_ GNILP 1141_ KTNGF 1146_ ILFLY 1151_ FSDYS 1156_ FSVIA 1161_ MSYLI 1166_ SVFFN 1171_ NTNIA 1176_ ALIGS 1181_ LIYII 1186_ AFFPF 1191_ IVLVT 1196_ VENEL 1201_ SYVLK 1206_ VFMSL 1211_ LSPTA 1216_ FSYAS 1221_ QYIAR 1226_ YEEQG 1231_ IGLQW 1236_ ENMYT 1241_ SPVQD 1246_ DTTSF 1251_ GWLCC 1256_ LILAD 1261_ SFIYF 1266_ LIAWY 1271_ VRNVF 1276_ PGTYG 1281_ MAAPW 1286_ YFPIL 1291_ PSYWK 1296_ ERFGC 1301_ AEVKP 1306_ EKSNG 1311_ LMFTN 1316_ IMMQN 1321_ TNPSA 1326_ SPEYM 1331_ FSSNI 1336_ EPEPK 1341_ DLTVG 1346_ VALHG 1351_ VTKIY 1356_ GSKVA 1361_ VDNLN 1366_ LNFYE 1371_ GHITS 1376_ LLGPN 1381_ GAGKT 1386_ TTISM 1391_ LTGLF 1396_ GASAG 1401_ TIFVY 1406_ GKDIK 1411_ TDLHT 1416_ VRKNM 1421_ GVCMQ 1426_ HDVLF 1431_ SYLTT 1436_ KEHLL 1441_ LYGSI 1446_ KVPHW 1451_ TKKQL 1456_ HEEVK 1461_ RTLKD 1466_ TGLYS 1471_ HRHKR 1476_ VGTLS 1481_ GGMKR 1486_ KLSIS 1491_ IALIG 1496_ GSRVV 1501_ ILDEP 1506_ STGVD 1511_ PCSRR 1516_ SIWDV 1521_ ISKNK 1526_ TARTI 1531_ ILSTH 1536_ HLDEA 1541_ EVLSD 1546_ RIAFL 1551_ EQGGL 1556_ RCCGS 1561_ PFYLK 1566_ EAFGD 1571_ GYHLT 1576_ LTKKK 1581_ SPNLN 1586_ ANAVC 1591_ DTMAV 1596_ TAMIQ 1601_ SHLPE 1606_ AYLKE 1611_ DIGGE 1616_ LVYVL 1621_ PPFST 1626_ KVSGA 1631_ YLSLL 1636_ RALDN 1641_ GMGDL 1646_ NIGCY 1651_ GISDT 1656_ TVEEV 1661_ FLNLT 1666_ KESQK 1671_ NSAMS 1676_ LEHLT 1681_ QKKIG 1686_ NSNAN 1691_ GISTP 1696_ DDLSV 1701_ SSSNF 1706_ TDRDD 1711_ KILTR 1716_ GERLD 1721_ GFGLL 1726_ LKKIM 1731_ AILIK 1736_ RFHHT 1741_ RRNWK 1746_ GLIAQ 1751_ VILPI 1756_ VFVTT 1761_ AMGLG 1766_ TLRNS 1771_ SNSYP 1776_ EIQIS 1781_ PSLYG 1786_ TSEQT 1791_ AFYAN 1796_ YHPST 1801_ EALVS 1806_ AMWDF 1811_ PGIDN 1816_ MCLNT 1821_ SDLQC 1826_ LNKDS 1831_ LEKWN 1836_ TSGEP 1841_ ITNFG 1846_ VCSCS 1851_ ENVQE 1856_ CPKFN 1861_ YSPPH 1866_ RRTYS 1871_ SQVIY 1876_ NLTGQ 1881_ RVENY 1886_ LISTA 1891_ NEFVQ 1896_ KRYGG 1901_ WSFGL 1906_ PLTKD 1911_ LRFDI 1916_ TGVPA 1921_ NRTLA 1926_ KVWYD 1931_ PEGYH 1936_ SLPAY 1941_ LNSLN 1946_ NFLLR 1951_ VNMSK 1956_ YDAAR 1961_ HGIIM 1966_ YSHPY 1971_ PGVQD 1976_ QEQAT 1981_ ISSLI 1986_ DILVA 1991_ LSILM 1996_ GYSVT 2001_ TASFV 2006_ TYVVR 2011_ EHQTK 2016_ AKQLQ 2021_ HISGI 2026_ GVTCY 2031_ WVTNF 2036_ IYDMV 2041_ FYLVP 2046_ VAFSI 2051_ GIIAI 2056_ FKLPA 2061_ FYSEN 2066_ NLGAV 2071_ SLLLL 2076_ LFGYA 2081_ TFSWM 2086_ YLLAG 2091_ LFHET 2096_ GMAFI 2101_ TYVCV 2106_ NLFFG 2111_ INSIV 2116_ SLSVV 2121_ YFLSK 2126_ EKPND 2131_ PTLEL 2136_ ISETL 2141_ KRIFL 2146_ IFPQF 2151_ CFGYG 2156_ LIELS 2161_ QQQSV 2166_ LDFLK 2171_ AYGVE 2176_ YPNET 2181_ FEMNK 2186_ LGAMF 2191_ VALVS 2196_ QGTMF 2201_ FSLRL 2206_ LINES 2211_ LIKKL 2216_ RLFFR 2221_ KFNSS 2226_ HVRET 2231_ IDEDE 2236_ DVRAE 2241_ RLRVE 2246_ SGAAE 2251_ FDLVQ 2256_ LYCLT 2261_ KTYQL 2266_ IHKKI 2271_ IAVNN 2276_ ISIGI 2281_ PAGEC 2286_ FGLLG 2291_ VNGAG 2296_ KTTIF 2301_ KMLTG 2306_ DIIPS 2311_ SGNIL 2316_ IRNKT 2321_ GSLGH 2326_ VDSHS 2331_ SLVGY 2336_ CPQED 2341_ ALDDL 2346_ VTVEE 2351_ HLYFY 2356_ ARVHG 2361_ IPEKD 2366_ IKETV 2371_ HKLLR 2376_ RLHLM 2381_ PFKDR 2386_ ATSMC 2391_ SYGTK 2396_ RKLST 2401_ ALALI 2406_ GKPSI 2411_ LLLDE 2416_ PSSGM 2421_ DPKSK 2426_ RHLWK 2431_ IISEE 2436_ VQNKC 2441_ SVILT 2446_ SHSME 2451_ ECEAL 2456_ CTRLA 2461_ IMVNG 2466_ KFQCI 2471_ GSLQH 2476_ IKSRF 2481_ GRGFT 2486_ VKVHL 2491_ KNNKV 2496_ TMETL 2501_ TKFMQ 2506_ LHFPK 2511_ TYLKD 2516_ QHLSM 2521_ LEYHV 2526_ PVTAG 2531_ GVANI 2536_ FDLLE 2541_ TNKTA 2546_ LNITN 2551_ FLVSQ 2556_ TTLEE 2561_ VFINF 2566_ AKDQK 2571_ SYETA 2576_ DTSSQ 2581_ GSTIS 2586_VDSQD
1: Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:16007253, PubMed:20869849). In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation (PubMed:19179616). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (By similarity). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (By similarity). Also involved in lung surfactant biogenesis (By similarity)