Reticulon-4 receptor-like 1 (Nogo receptor-like 2) (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3)
1_MLRKG 6_ CCVEL 11_ LLLLV 16_ AAELP 21_ LGGGC 26_ PRDCV 31_ CYPAP 36_ MTVSC 41_ QAHNF 46_ AAIPE 51_ GIPVD 56_ SERVF 61_ LQNNR 66_ IGLLQ 71_ PGHFS 76_ PAMVT 81_ LWIYS 86_ NNITY 91_ IHPST 96_ FEGFV 101_ HLEEL 106_ DLGDN 111_ RQLRT 116_ LAPET 121_ FQGLV 126_ KLHAL 131_ YLYKC 136_ GLSAL 141_ PAGVF 146_ GGLHS 151_ LQYLY 156_ LQDNH 161_ IEYLQ 166_ DDIFV 171_ DLVNL 176_ SHLFL 181_ HGNKL 186_ WSLGP 191_ GTFRG 196_ LVNLD 201_ RLLLH 206_ ENQLQ 211_ WVHHK 216_ AFHDL 221_ RRLTT 226_ LFLFN 231_ NSLSE 236_ LQGEC 241_ LAPLG 246_ ALEFL 251_ RLNGN 256_ PWDCG 261_ CRARS 266_ LWEWL 271_ QRFRG 276_ SSSAV 281_ PCVSP 286_ GLRHG 291_ QDLKL 296_ LRAED 301_ FRNCT 306_ GPASP 311_ HQIKS 316_ HTLTT 321_ TDRAA 326_ RKEHH 331_ SPHGP 336_ TRSKG 341_ HPHGP 346_ RPGHR 351_ KPGKN 356_ CTNPR 361_ NRNQI 366_ SKAGA 371_ GKQAP 376_ ELPDY 381_ APDYQ 386_ HKFSF 391_ DIMPT 396_ ARPKR 401_ KGKCA 406_ RRTPI 411_ RAPSG 416_ VQQAS 421_ SASSL 426_ GASLL 431_ AWTLG 436_LAVTL
1: Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)