Reticulon-4 receptor-like 2 (Nogo receptor-like 3) (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2)
1_MLPGL 6_ RRLLQ 11_ APASA 16_ CLLLM 21_ LLALP 26_ LAAPS 31_ CPMLC 36_ TCYSS 41_ PPTVS 46_ CQANN 51_ FSSVP 56_ LSLPP 61_ STQRL 66_ FLQNN 71_ LIRTL 76_ RPGTF 81_ GSNLL 86_ TLWLF 91_ SNNLS 96_ TIYPG 101_ TFRHL 106_ QALEE 111_ LDLGD 116_ NRHLR 121_ SLEPD 126_ TFQGL 131_ ERLQS 136_ LHLYR 141_ CQLSS 146_ LPGNI 151_ FRGLV 156_ SLQYL 161_ YLQEN 166_ SLLHL 171_ QDDLF 176_ ADLAN 181_ LSHLF 186_ LHGNR 191_ LRLLT 196_ EHVFR 201_ GLGSL 206_ DRLLL 211_ HGNRL 216_ QGVHR 221_ AAFRG 226_ LSRLT 231_ ILYLF 236_ NNSLA 241_ SLPGE 246_ ALADL 251_ PSLEF 256_ LRLNA 261_ NPWAC 266_ DCRAR 271_ PLWAW 276_ FQRAR 281_ VSSSD 286_ VTCAT 291_ PPERQ 296_ GRDLR 301_ ALREA 306_ DFQAC 311_ PPAAP 316_ TRPGS 321_ RARGN 326_ SSSNH 331_ LYGVA 336_ EAGAP 341_ PADPS 346_ TLYRD 351_ LPAED 356_ SRGRQ 361_ GGDAP 366_ TEDDY 371_ WGGYG 376_ GEDQR 381_ GEQMC 386_ PGAAC 391_ QAPPD 396_ SRGPA 401_ LSAGL 406_ PSPLL 411_CLLLL
1: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)