Transcription factor NF-E4
1_MPRVV 6_ CWHTL 11_ KSLNG 16_ YKNLS 21_ SGAET 26_ REGLR 31_ SSSPV 36_ DLPLR 41_ PRKQA 46_ TAAGQ 51_ RKLLS 56_ LQLLL 61_ CACTS 66_ VTDLT 71_ YWGPA 76_ GHGAT 81_ APHRS 86_ LLAIH 91_ LHLVP 96_ ASSAA 101_ MKATG 106_ PHNAQ 111_ TQVNP 116_ QGHAP 121_ SAEDP 126_ TGTWT 131_ VSGPC 136_ KDHPH 141_ PFLSQ 146_ SNPPT 151_ RISSA 156_ LPLKT 161_ DSALE 166_ QTPQQ 171_LPSLH
1: Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter