Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a)
1_MAEGL 6_ ERVRI 11_ SASEL 16_ RGILA 21_ TLAPQ 26_ AGSRE 31_ NMKEL 36_ KEARP 41_ RKDNR 46_ RPDLE 51_ IYKPG 56_ LSRLR 61_ NKPKI 66_ KEPPG 71_ SEEFK 76_ DEIVN 81_ DRDCS 86_ AVENG 91_ TQPVK 96_ DVCKE 101_ LNNQE 106_ QNGPI 111_ DPENN 116_ RGQES 121_ FPRTA 126_ GQEDR 131_ SLKII 136_ KRTKK 141_ PDLQI 146_ YQPGR 151_ RLQTV 156_ SKESA 161_ SRVEE 166_ EEVLN 171_ QVEQL 176_ RVEED 181_ ECRGN 186_ VAKEE 191_ VANKP 196_ DRAEI 201_ EKSPG 206_ GGRVG 211_ AAKGE 216_ KGKRM 221_ GKGEG 226_ VRETH 231_ DDPAR 236_ GRPGS 241_ AKRYS 246_ RSDKR 251_ RNRYR 256_ TRSTS 261_ SAGSN 266_ NSAEG 271_ AGLTD 276_ NGCRR 281_ RRQDR 286_ TKERP 291_ RLKKQ 296_ VSVSS 301_ TDSLD 306_ EDRID 311_ EPDGL 316_ GPRRS 321_ SERKR 326_ HLERN 331_ WSGRG 336_ EGEQK 341_ NSAKE 346_ YRGTL 351_ RVTFD 356_ AEAMN 361_ KESPM 366_ VRSAR 371_ DDMDR 376_ GKPDK 381_ GLSSG 386_ GKGSE 391_ KQESK 396_ NPKQE 401_ LRGRG 406_ RGILI 411_ LPAHT 416_ TLSVN 421_ SAGSP 426_ ESAPL 431_ GPRLL 436_ FGSGS 441_ KGSRS 446_ WGRGG 451_ TTRRL 456_ WDPNN 461_ PDQKP 466_ ALKTQ 471_ TPQLH 476_ FLDTD 481_ DEVSP 486_ TSWGD 491_ SRQAQ 496_ ASYYK 501_ FQNSD 506_ NPYYY 511_ PRTPG 516_ PASQY 521_ PYTGY 526_ NPLQY 531_ PVGPT 536_ NGVYP 541_ GPYYP 546_ GYPTP 551_ SGQYV 556_ CSPLP 561_ TSTMS 566_ PEEVE 571_ QHMRN 576_ LQQQE 581_ LHRLL 586_ RVADN 591_ QELQL 596_ SNLLS 601_ RDRIS 606_ PEGLE 611_ KMAQL 616_ RAELL 621_ QLYER 626_ CILLD 631_ IEFSD 636_ NQNVD 641_ QILWK 646_ NAFYQ 651_ VIEKF 656_ RQLVK 661_ DPNVE 666_ NPEQI 671_ RNRLL 676_ ELLDE 681_ GSDFF 686_ DSLLQ 691_ KLQVT 696_ YKFKL 701_ EDYMD 706_ GLAIR 711_ SKPLR 716_ KTVKY 721_ ALISA 726_ QRCMI 731_ CQGDI 736_ ARYRE 741_ QASDT 746_ ANYGK 751_ ARSWY 756_ LKAQH 761_ IAPKN 766_ GRPYN 771_ QLALL 776_ AVYTR 781_ RKLDA 786_ VYYYM 791_ RSLAA 796_ SNPIL 801_ TAKES 806_ LMSLF 811_ EETKR 816_ KAEQM 821_ EKKQH 826_ EEFDL 831_ SPDQW 836_ RKGKK 841_ STFRH 846_ VGDDT 851_ TRLEI 856_ WIHPS 861_ HPRSS 866_ QGTES 871_ GKDSE 876_ QENGL 881_ GSLSP 886_ SDLNK 891_ RFILS 896_ FLHAH 901_ GKLFT 906_ RIGME 911_ TFPAV 916_ AEKVL 921_ KEFQV 926_ LLQHS 931_ PSPIG 936_ STRML 941_ QLMTI 946_ NMFAV 951_ HNSQL 956_ KDCFS 961_ EECRS 966_ VIQEQ 971_ AAALG 976_ LAMFS 981_ LLVRR 986_ CTCLL 991_ KESAK 996_ AQLSS 1001_ PEDQD 1006_ DQDDI 1011_ KVSSF 1016_ VPDLK 1021_ ELLPS 1026_ VKVWS 1031_ DWMLG 1036_ YPDTW 1041_ NPPPT 1046_ SLDLP 1051_ SHVAV 1056_ DVWST 1061_ LADFC 1066_ NILTA 1071_ VNQSE 1076_ VPLYK 1081_ DPDDD 1086_ LTLLI 1091_ LEEDR 1096_ LLSGF 1101_ VPLLA 1106_ APQDP 1111_ CYVEK 1116_ TSDKV 1121_ IAADC 1126_ KRVTV 1131_ LKYFL 1136_ EALCG 1141_ QEEPL 1146_ LAFKG 1151_ GKYVS 1156_ VAPVP 1161_ DTMGK 1166_ EMGSQ 1171_ EGTRL 1176_ EDEEE 1181_ DVVIE 1186_ DFEED 1191_ SEAEG 1196_ SGGED 1201_ DIREL 1206_ RAKKL 1211_ ALARK 1216_ IAEQQ 1221_ RRQEK 1226_ IQAVL 1231_ EDHSQ 1236_ MRQME 1241_ LEIRP 1246_ LFLVP 1251_ DTNGF 1256_ IDHLA 1261_ SLARL 1266_ LESRK 1271_ YILVV 1276_ PLIVI 1281_ NELDG 1286_ LAKGQ 1291_ ETDHR 1296_ AGGYA 1301_ RVVQE 1306_ KARKS 1311_ IEFLE 1316_ QRFES 1321_ RDSCL 1326_ RALTS 1331_ RGNEL 1336_ ESIAF 1341_ RSEDI 1346_ TGQLG 1351_ NNDDL 1356_ ILSCC 1361_ LHYCK 1366_ DKAKD 1371_ FMPAS 1376_ KEEPI 1381_ RLLRE 1386_ VVLLT 1391_ DDRNL 1396_ RVKAL 1401_ TRNVP 1406_ VRDIP 1411_AFLTW
1: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629)
2: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030)