NLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 26) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9)
1_MRWGH 6_ HLPRA 11_ SWGSG 16_ FRRAL 21_ QRPDD 26_ RIPFL 31_ IHWSW 36_ PLQGE 41_ RPFGP 46_ PRAFI 51_ RHHGS 56_ SVDSA 61_ PPPGR 66_ HGRLF 71_ PSASA 76_ TEAIQ 81_ RHRRN 86_ LAEWF 91_ SRLPR 96_ EERQF 101_ GPTFA 106_ LDTVH 111_ VDPVI 116_ RESTP 121_ DELLR 126_ PPAEL 131_ ALEHQ 136_ PPQAG 141_ LPPLA 146_ LSQLF 151_ NPDAC 156_ GRRVQ 161_ TVVLY 166_ GTVGT 171_ GKSTL 176_ VRKMV 181_ LDWCY 186_ GRLPA 191_ FELLI 196_ PFSCE 201_ DLSSL 206_ GPAPA 211_ SLCQL 216_ VAQRY 221_ TPLKE 226_ VLPLM 231_ AAAGS 236_ HLLFV 241_ LHGLE 246_ HLNLD 251_ FRLAG 256_ TGLCS 261_ DPEEP 266_ QEPAA 271_ IIVNL 276_ LRKYM 281_ LPQAS 286_ ILVTT 291_ RPSAI 296_ GRIPS 301_ KYVGR 306_ YGEIC 311_ GFSDT 316_ NLQKL 321_ YFQLR 326_ LNQPY 331_ CGYAV 336_ GGSGV 341_ SATPA 346_ QRDHL 351_ VQMLS 356_ RNLEG 361_ HHQIA 366_ AACFL 371_ PSYCW 376_ LVCAT 381_ LHFLH 386_ APTPA 391_ GQTLT 396_ SIYTS 401_ FLRLN 406_ FSGET 411_ LDSTD 416_ PSNLS 421_ LMAYA 426_ ARTMG 431_ KLAYE 436_ GVSSR 441_ KTYFS 446_ EEDVC 451_ GCLEA 456_ GIRTE 461_ EEFQL 466_ LHIFR 471_ RDALR 476_ FFLAP 481_ CVEPG 486_ RAGTF 491_ VFTVP 496_ AMQEY 501_ LAALY 506_ IVLGL 511_ RKTTL 516_ QKVGK 521_ EVAEL 526_ VGRVG 531_ EDVSL 536_ VLGIM 541_ AKLLP 546_ LRALP 551_ LLFNL 556_ IKVVP 561_ RVFGR 566_ MVGKS 571_ REAVA 576_ QAMVL 581_ EMFRE 586_ EDYYN 591_ DDVLD 596_ QMGAS 601_ ILGVE 606_ GPRRH 611_ PDEPP 616_ EDEVF 621_ ELFPM 626_ FMGGL 631_ LSAHN 636_ RAVLA 641_ QLGCP 646_ IKNLD 651_ ALENA 656_ QAIKK 661_ KLGKL 666_ GRQVL 671_ PPSEL 676_ LDHLF 681_ FHYEF 686_ QNQRF 691_ SAEVL 696_ SSLRQ 701_ LNLAG 706_ VRMTP 711_ VKCTV 716_ VAAVL 721_ GSGRH 726_ ALDEV 731_ NLASC 736_ QLDPA 741_ GLRTL 746_ LPVFL 751_ RARKL 756_ GLQLN 761_ SLGPE 766_ ACKDL 771_ RDLLL 776_ HDQCQ 781_ ITTLR 786_ LSNNP 791_ LTAAG 796_ VAVLM 801_ EGLAG 806_ NTSVT 811_ HLSLL 816_ HTGLG 821_ DEGLE 826_ LLAAQ 831_ LDRNR 836_ QLQEL 841_ NVAYN 846_ GAGDT 851_ AALAL 856_ ARAAR 861_ EHPSL 866_ ELLHL 871_ YFNEL 876_ SSEGR 881_ QVLRD 886_ LGGAA 891_ EGGAR 896_ VVVSL 901_ TEGTA 906_ VSEYW 911_ SVILS 916_ EVQRN 921_ LNSWD 926_ RARVQ 931_ RHLEL 936_ LLRDL 941_ EDSRG 946_ ATLNP 951_ WRKAQ 956_ LLRVE 961_ GEVRA 966_LLEQL
1: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity)