Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84)
1_MAPAQ 6_ RCPLC 11_ RQTFF 16_ CGRGH 21_ VYSRK 26_ HQRQL 31_ KEALE 36_ RLLPQ 41_ VEAAR 46_ KAIRA 51_ AQVER 56_ YVPEH 61_ ERCCW 66_ CLCCG 71_ CEVRE 76_ HLSHG 81_ NLTVL 86_ YGGLL 91_ EHLAS 96_ PEHKK 101_ ATNKF 106_ WWENK 111_ AEVQM 116_ KEKFL 121_ VTPQD 126_ YARFK 131_ KSMVK 136_ GLDSY 141_ EEKED 146_ KVIKE 151_ MAAQI 156_ REVEQ 161_ SRQEV 166_ VRSVL 171_ EPQAV 176_ PDPEE 181_ GSSAP 186_ RSWKG 191_ MNSQV 196_ ASSLQ 201_ QPSNL 206_ DLPPA 211_ PELDW 216_ METGP 221_ SLTFI 226_ GHQDI 231_ PGVGN 236_ IHSGA 241_ TPPWM 246_ IQDEE 251_ YIAGN 256_ QEIGP 261_ SYEEF 266_ LKEKE 271_ KQKLK 276_ KLPPD 281_ RVGAN 286_ FDHSS 291_ RTSAG 296_ WLPSF 301_ GRVWN 306_ NGRRW 311_ QSRHQ 316_ FKTEA 321_ AAMKK 326_QSHTE
1: Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype (PubMed:34009673). Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219)