Tachykinin-4 (Preprotachykinin-C) (PPT-C) [Cleaved into: Endokinin-A (EKA); Endokinin-A/B (EKA/B); Endokinin-C (EKC)]
1_MLPCL 6_ ALLLL 11_ MELSV 16_ CTVAG 21_ DGGEE 26_ QTLST 31_ EAETW 36_ VIVAL 41_ EEGAG 46_ PSIQL 51_ QLQEV 56_ KTGKA 61_ SQFFG 66_ LMGKR 71_ VGGRP 76_ LIQPR 81_ RKKAY 86_ QLEHT 91_ FQGLL 96_ GKRSL 101_ FTEGR 106_EDEAQ
1: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility