Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)
1_MAPRL 6_ QLEKA 11_ AWRWA 16_ ETVRP 21_ EEVSQ 26_ EHIET 31_ AYRIW 36_ LEPCI 41_ RGVCR 46_ RNCKG 51_ NPNCL 56_ VGIGE 61_ HIWLG 66_ EIDEN 71_ SFHNI 76_ DDPNC 81_ ERRKK 86_ NSFVG 91_ LTNLG 96_ ATCYV 101_ NTFLQ 106_ VWFLN 111_ LELRQ 116_ ALYLC 121_ PSTCS 126_ DYMLG 131_ DGIQE 136_ EKDYE 141_ PQTIC 146_ EHLQY 151_ LFALL 156_ QNSNR 161_ RYIDP 166_ SGFVK 171_ ALGLD 176_ TGQQQ 181_ DAQEF 186_ SKLFM 191_ SLLED 196_ TLSKQ 201_ KNPDV 206_ RNIVQ 211_ QQFCG 216_ EYAYV 221_ TVCNQ 226_ CGRES 231_ KLLSK 236_ FYELE 241_ LNIQG 246_ HKQLT 251_ DCISE 256_ FLKEE 261_ KLEGD 266_ NRYFC 271_ ENCQS 276_ KQNAT 281_ RKIRL 286_ LSLPC 291_ TLNLQ 296_ LMRFV 301_ FDRQT 306_ GHKKK 311_ LNTYI 316_ GFSEI 321_ LDMEP 326_ YVEHK 331_ GGSYV 336_ YELSA 341_ VLIHR 346_ GVSAY 351_ SGHYI 356_ AHVKD 361_ PQSGE 366_ WYKFN 371_ DEDIE 376_ KMEGK 381_ KLQLG 386_ IEEDL 391_ AEPSK 396_ SQTRK 401_ PKCGK 406_ GTHCS 411_ RNAYM 416_ LVYRL 421_ QTQEK 426_ PNTTV 431_ QVPAF 436_ LQELV 441_ DRDNS 446_ KFEEW 451_ CIEMA 456_ EMRKQ 461_ SVDKG 466_ KAKHE 471_ EVKEL 476_ YQRLP 481_ AGAEP 486_ YEFVS 491_ LEWLQ 496_ KWLDE 501_ STPTK 506_ PIDNH 511_ ACLCS 516_ HDKLH 521_ PDKIS 526_ IMKRI 531_ SEYAA 536_ DIFYS 541_ RYGGG 546_ PRLTV 551_ KALCK 556_ ECVVE 561_ RCRIL 566_ RLKNQ 571_ LNEDY 576_ KTVNN 581_ LLKAA 586_ VKGSD 591_ GFWVG 596_ KSSLR 601_ SWRQL 606_ ALEQL 611_ DEQDG 616_ DAEQS 621_ NGKMN 626_ GSTLN 631_ KDESK 636_ EERKE 641_ EEELN 646_ FNEDI 651_ LCPHG 656_ ELCIS 661_ ENERR 666_ LVSKE 671_ AWSKL 676_ QQYFP 681_ KAPEF 686_ PSYKE 691_ CCSQC 696_ KILER 701_ EGEEN 706_ EALHK 711_ MIANE 716_ QKTSL 721_ PNLFQ 726_ DKNRP 731_ CLSNW 736_ PEDTD 741_ VLYIV 746_ SQFFV 751_ EEWRK 756_ FVRKP 761_ TRCSP 766_ VSSVG 771_ NSALL 776_ CPHGG 781_ LMFTF 786_ ASMTK 791_ EDSKL 796_ IALIW 801_ PSEWQ 806_ MIQKL 811_ FVVDH 816_ VIKIT 821_ RIEVG 826_ DVNPS 831_ ETQYI 836_ SEPKL 841_ CPECR 846_ EGLLC 851_ QQQRD 856_ LREYT 861_ QATIY 866_ VHKVV 871_ DNKKV 876_ MKDSA 881_ PELNV 886_ SSSET 891_ EEDKE 896_ EAKPD 901_ GEKDP 906_ DFNQS 911_ NGGTK 916_ RQKIS 921_ HQNYI 926_ AYQKQ 931_ VIRRS 936_ MRHRK 941_ VRGEK 946_ ALLVS 951_ ANQTL 956_ KELKI 961_ QIMHA 966_ FSVAP 971_ FDQNL 976_ SIDGK 981_ ILSDD 986_ CATLG 991_ TLGVI 996_ PESVI 1001_ LLKAD 1006_ EPIAD 1011_ YAAMD 1016_ DVMQV 1021_ CMPEE 1026_GFKGT
1: Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins (PubMed:16214042, PubMed:34059922). Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability (PubMed:34445214). In the context of H.pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death (PubMed:35913642). Also functions in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms (PubMed:36293380). Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination (PubMed:36607699)