Organic solute transporter subunit alpha (OST-alpha) (Solute carrier family 51 subunit alpha)
1_MEPGR 6_ TQIKL 11_ DPRYT 16_ ADLLE 21_ VLKTN 26_ YGIPS 31_ ACFSQ 36_ PPTAA 41_ QLLRA 46_ LGPVE 51_ LALTS 56_ ILTLL 61_ ALGSI 66_ AIFLE 71_ DAVYL 76_ YKNTL 81_ CPIKR 86_ RTLLW 91_ KSSAP 96_ TVVSV 101_ LCCFG 106_ LWIPR 111_ SLVLV 116_ EMTIT 121_ SFYAV 126_ CFYLL 131_ MLVMV 136_ EGFGG 141_ KEAVL 146_ RTLRD 151_ TPMMV 156_ HTGPC 161_ CCCCP 166_ CCPRL 171_ LLTRK 176_ KLQLL 181_ MLGPF 186_ QYAFL 191_ KITLT 196_ LVGLF 201_ LVPDG 206_ IYDPA 211_ DISEG 216_ STALW 221_ INTFL 226_ GVSTL 231_ LALWT 236_ LGIIS 241_ RQARL 246_ HLGEQ 251_ NMGAK 256_ FALFQ 261_ VLLIL 266_ TALQP 271_ SIFSV 276_ LANGG 281_ QIACS 286_ PPYSS 291_ KTRSQ 296_ VMNCH 301_ LLILE 306_ TFLMT 311_ VLTRM 316_ YYRRK 321_ DHKVG 326_ YETFS 331_SPDLD
1: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684). Efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity)