Organic solute transporter subunit beta (OST-beta) (Solute carrier family 51 subunit beta)
1_MEHSE 6_ GAPGD 11_ PAGTV 16_ VPQEL 21_ LEEML 26_ WFFRV 31_ EDASP 36_ WNHSI 41_ LALAA 46_ VVVII 51_ SMVLL 56_ GRSIQ 61_ ASRKE 66_ KMQPP 71_ EKETP 76_ EVLHL 81_ DEAKD 86_ HNSLN 91_ NLRET 96_ LLSEK 101_ PNLAQ 106_ VELEL 111_ KERDV 116_ LSVFL 121_PDVPE
1: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684). Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:16317684). The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity)