Gene name: HAPLN4

Uniprot entry:

Q86UW8

Protein names:

Hyaluronan and proteoglycan link protein 4 (Brain link protein 2)

Protein sequence:

1_MVCAR 6_ AALGP 11_ GALWA 16_ AAWGV 21_ LLLTA 26_ PAGAQ 31_ RGRKK 36_ VVHVL 41_ EGESG 46_ SVVVQ 51_ TAPGQ 56_ VVSHR 61_ GGTIV 66_ LPCRY 71_ HYEAA 76_ AHGHD 81_ GVRLK 86_ WTKVV 91_ DPLAF 96_ TDVFV 101_ ALGPQ 106_ HRAFG 111_ SYRGR 116_ AELQG 121_ DGPGD 126_ ASLVL 131_ RNVTL 136_ QDYGR 141_ YECEV 146_ TNELE 151_ DDAGM 156_ VKLDL 161_ EGVVF 166_ PYHPR 171_ GGRYK 176_ LTFAE 181_ AQRAC 186_ AEQDG 191_ ILASA 196_ EQLHA 201_ AWRDG 206_ LDWCN 211_ AGWLR 216_ DGSVQ 221_ YPVNR 226_ PREPC 231_ GGLGG 236_ TGSAG 241_ GGGDA 246_ NGGLR 251_ NYGYR 256_ HNAEE 261_ RYDAF 266_ CFTSN 271_ LPGRV 276_ FFLKP 281_ LRPVP 286_ FSGAA 291_ RACAA 296_ RGAAV 301_ AKVGQ 306_ LFAAW 311_ KLQLL 316_ DRCTA 321_ GWLAD 326_ GSARY 331_ PIVNP 336_ RARCG 341_ GRRPG 346_ VRSLG 351_ FPDAT 356_ RRLFG 361_ VYCYR 366_ APGAP 371_ DPAPG 376_ GWGWG 381_ WAGGG 386_ GWAGG 391_ ARDPA 396_AWTPL

Protein annotations

Protein functions:

1: Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (By similarity). Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons (By similarity)