Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2)
1_MAMAP 6_ SPSLV 11_ QVYTS 16_ PAAVA 21_ VWEWQ 26_ DGLGT 31_ WHPYS 36_ ATVCS 41_ FIEQQ 46_ FVQQK 51_ GQRFG 56_ LGSLA 61_ HSIPL 66_ GQADP 71_ SLAPY 76_ IIDLP 81_ SWTQF 86_ RQDTG 91_ TMRAV 96_ RRHLF 101_ PQHSA 106_ PGRGV 111_ VWEWL 116_ SDDGS 121_ WTAYE 126_ ASVCD 131_ YLEQQ 136_ VARGN 141_ QLVDL 146_ APLGY 151_ NYTVN 156_ YTTHT 161_ QTNKT 166_ SSFCR 171_ SVRRQ 176_ AGPPY 181_ PVTTI 186_ IAPPG 191_ HTGVA 196_ CSCHQ 201_ CLSGS 206_ RTGPV 211_ SGRYR 216_ HSMTN 221_ LPAYP 226_ VPQHP 231_ PHRTA 236_ SVFGT 241_ HQAFA 246_ PYNKP 251_ SLSGA 256_ RSAPR 261_ LNTTN 266_ AWGAA 271_ PPSLG 276_ SQPLY 281_ RSSLS 286_ HLGPQ 291_ HLPPG 296_ SSTSG 301_ AVSAS 306_ LPSGP 311_ SSSPG 316_ SVPAT 321_ VPMQM 326_ PKPSR 331_ VQQAL 336_ AGMTS 341_ VLMSA 346_ IGLPV 351_ CLSRA 356_ PQPTS 361_ PPASR 366_ LASKS 371_ HGSVK 376_ RLRKM 381_ SVKGA 386_ TPKPE 391_ PEPEQ 396_ VIKNY 401_ TEELK 406_ VPPDE 411_ DCIIC 416_ MEKLS 421_ TASGY 426_ SDVTD 431_ SKAIG 436_ SLAVG 441_ HLTKC 446_ SHAFH 451_ LLCLL 456_ AMYCN 461_ GNKDG 466_ SLQCP 471_ SCKTI 476_ YGEKT 481_ GTQPQ 486_ GKMEV 491_ LRFQM 496_ SLPGH 501_ EDCGT 506_ ILIVY 511_ SIPHG 516_ IQGPE 521_ HPNPG 526_ KPFTA 531_ RGFPR 536_ QCYLP 541_ DNAQG 546_ RKVLE 551_ LLKVA 556_ WKRRL 561_ IFTVG 566_ TSSTT 571_ GETDT 576_ VVWNE 581_ IHHKT 586_ EMDRN 591_ ITGHG 596_ YPDPN 601_ YLQNV 606_ LAELA 611_ AQGVT 616_EDCLE
1: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity