Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2)
1_MAGMK 6_ TASGD 11_ YIDSS 16_ WELRV 21_ FVGEE 26_ DPEAE 31_ SVTLR 36_ VTGES 41_ HIGGV 46_ LLKIV 51_ EQINR 56_ KQDWS 61_ DHAIW 66_ WEQKR 71_ QWLLQ 76_ THWTL 81_ DKYGI 86_ LADAR 91_ LFFGP 96_ QHRPV 101_ ILRLP 106_ NRRAL 111_ RLRAS 116_ FSQPL 121_ FQAVA 126_ AICRL 131_ LSIRH 136_ PEELS 141_ LLRAP 146_ EKKEK 151_ KKKEK 156_ EPEEE 161_ LYDLS 166_ KVVLA 171_ GGVAP 176_ ALFRG 181_ MPAHF 186_ SDSAQ 191_ TEACY 196_ HMLSR 201_ PQPPP 206_ DPLLL 211_ QRLPR 216_ PSSLS 221_ DKTQL 226_ HSRWL 231_ DSSRC 236_ LMQQG 241_ IKAGD 246_ ALWLR 251_ FKYYS 256_ FFDLD 261_ PKTDP 266_ VRLTQ 271_ LYEQA 276_ RWDLL 281_ LEEID 286_ CTEEE 291_ MMVFA 296_ ALQYH 301_ INKLS 306_ QSGEV 311_ GEPAG 316_ TDPGL 321_ DDLDV 326_ ALSNL 331_ EVKLE 336_ GSAPT 341_ DVLDS 346_ LTTIP 351_ ELKDH 356_ LRIFR 361_ IPRRP 366_ RKLTL 371_ KGYRQ 376_ HWVVF 381_ KETTL 386_ SYYKS 391_ QDEAP 396_ GDPIQ 401_ QLNLK 406_ GCEVV 411_ PDVNV 416_ SGQKF 421_ CIKLL 426_ VPSPE 431_ GMSEI 436_ YLRCQ 441_ DEQQY 446_ ARWMA 451_ GCRLA 456_ SKGRT 461_ MADSS 466_ YTSEV 471_ QAILA 476_ FLSLQ 481_ RTGSG 486_ GPGNH 491_ PHGPD 496_ ASAEG 501_ LNPYG 506_ LVAPR 511_ FQRKF 516_ KAKQL 521_ TPRIL 526_ EAHQN 531_ VAQLS 536_ LAEAQ 541_ LRFIQ 546_ AWQSL 551_ PDFGI 556_ SYVMV 561_ RFKGS 566_ RKDEI 571_ LGIAN 576_ NRLIR 581_ IDLAV 586_ GDVVK 591_ TWRFS 596_ NMRQW 601_ NVNWD 606_ IRQVA 611_ IEFDE 616_ HINVA 621_ FSCVS 626_ ASCRI 631_ VHEYI 636_ GGYIF 641_ LSTRE 646_ RARGE 651_ ELDED 656_ LFLQL 661_TGGHE
1: Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity)
2: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis