N-alpha-acetyltransferase 40 (EC 2.3.1.257) (N-acetyltransferase 11) (N-alpha-acetyltransferase D) (NatD) (hNatD) (Protein acetyltransferase 1)
1_MGRKS 6_ SKAKE 11_ KKQKR 16_ LEERA 21_ AMDAV 26_ CAKVD 31_ AANRL 36_ GDPLE 41_ AFPVF 46_ KKYDR 51_ NGLNV 56_ SIECK 61_ RVSGL 66_ EPATV 71_ DWAFD 76_ LTKTN 81_ MQTMY 86_ EQSEW 91_ GWKDR 96_ EKREE 101_ MTDDR 106_ AWYLI 111_ AWENS 116_ SVPVA 121_ FSHFR 126_ FDVEC 131_ GDEVL 136_ YCYEV 141_ QLESK 146_ VRRKG 151_ LGKFL 156_ IQILQ 161_ LMANS 166_ TQMKK 171_ VMLTV 176_ FKHNH 181_ GAYQF 186_ FREAL 191_ QFEID 196_ DSSPS 201_ MSGCC 206_ GEDCS 211_ YEILS 216_ RRTKF 221_ GDSHH 226_ SHAGG 231_HCGGC
1: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity)