Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2)
1_MSGGS 6_ QVHIF 11_ WGAPI 16_ APLKI 21_ TVSED 26_ TASLM 31_ SVADP 36_ WKKIQ 41_ LLYSQ 46_ HSLYL 51_ KDEKQ 56_ HKNLE 61_ NYKVP 66_ ESIGS 71_ PDLSG 76_ HFLAN 81_ CMNRH 86_ VHVKD 91_ DFVRS 96_ VSETQ 101_ NIESQ 106_ KIHSS 111_ RLSDI 116_ TSSNM 121_ QICGF 126_ KSTVP 131_ HFTEE 136_ EKYQK 141_ LLSEN 146_ KIRDE 151_ QPKHQ 156_ PDICG 161_ KNFNT 166_ NLFQL 171_ GHKCA 176_ AVLDL 181_ VCSTE 186_ KINIG 191_ PEVVQ 196_ RECVP 201_ TEYHE 206_ IQNQC 211_ LGLFS 216_ SNAVD 221_ KSRSE 226_ AAVRK 231_ VSDLK 236_ ISTDT 241_ EFLSI 246_ ITSSQ 251_ VAFLA 256_ QKKDK 261_ RRSPV 266_ NKGNV 271_ NMETE 276_ PKASY 281_ GEIRI 286_ PEENS 291_ IQLDG 296_ FTEAY 301_ ESGQN 306_ QAYSL 311_ ELFSP 316_ VCPKT 321_ ENSRI 326_ HINSD 331_ KGLEE 336_ HTGSQ 341_ ELFSS 346_ EDELP 351_ PNEIR 356_ IELCS 361_ SGILC 366_ SQLNT 371_ FHKSA 376_ IKRSC 381_ TSEDK 386_ VGQSE 391_ ALSRV 396_ LQVAK 401_ KMKLI 406_ SNGGD 411_ SAVEM 416_ DRRNV 421_ SEFKS 426_ IKKTS 431_ LIKNC 436_ DSKSQ 441_ KYNCL 446_ VMVLS 451_ PCHVK 456_ EINIK 461_ FGPNS 466_ GSKVP 471_ LATVT 476_ VIDQS 481_ ETKKK 486_ VFLWR 491_ TAAFW 496_ AFTVF 501_ LGDII 506_ LLTDV 511_ VIHED 516_ QWIGE 521_ TVLQS 526_ TFSSQ 531_ LLNLG 536_ SYSSI 541_ QPEEY 546_ SSVVS 551_ EVVLQ 556_ DLLAY 561_ VSSKH 566_ SYLRD 571_ LPPRQ 576_ PQRVN 581_ SIDFV 586_ ELEHL 591_ QPDVL 596_ VHAVL 601_ RVVDF 606_ TILTE 611_ AVYSY 616_ RGQKQ 621_ KKVML 626_ TVEQA 631_ QDQHY 636_ ALVLW 641_ GPGAA 646_ WYPQL 651_ QRKKG 656_ VVLIK 661_ AQISE 666_ LAFPI 671_ TASQK 676_ IALNA 681_ HSSLK 686_ SIFSS 691_ LPNIV 696_ YTGCA 701_ KCGLE 706_ LETDE 711_ NRIYK 716_ QCFSC 721_ LPFTM 726_ KKIYY 731_ RPALM 736_ TAIDG 741_ RHDVC 746_ IRVES 751_ KLIEK 756_ ILLNI 761_ SADCL 766_ NRVIV 771_ PSSEI 776_ TYGMV 781_ VADLF 786_ HSLLA 791_ VSAEP 796_ CVLKI 801_ QSLFV 806_ LDENS 811_ YPLQQ 816_ DFSLL 821_ DFYPD 826_IVKHG
1: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893)