Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein)
1_MTGSA 6_ ADTHR 11_ CPHPK 16_ GAKGT 21_ RSRSS 26_ HARPV 31_ SLATS 36_ GGSEE 41_ EDKDG 46_ GVLFH 51_ VNKSG 56_ FPIDS 61_ HTWER 66_ MWMHV 71_ AKVHP 76_ KGGEM 81_ VGAIR 86_ NAAFL 91_ AKPSI 96_ PQVPN 101_ YRLSM 106_ TIPDW 111_ LQAIQ 116_ NYMKT 121_ LQYNH 126_ TGTQF 131_ FEIRK 136_ MRPLS 141_ GLMET 146_ AKEMT 151_ RESLP 156_ IKCLE 161_ AVILG 166_ IYLTN 171_ GQPSI 176_ ERFPI 181_ SFKTY 186_ FSGNY 191_ FHHVV 196_ LGIYC 201_ NGRYG 206_ SLGMS 211_ RRAEL 216_ MDKPL 221_ TFRTL 226_ SDLIF 231_ DFEDS 236_ YKKYL 241_ HTVKK 246_ VKIGL 251_ YVPHE 256_ PHSFQ 261_ PIEWK 266_ QLVLN 271_ VSKML 276_ RADIR 281_ KELEK 286_ YARDM 291_ RMKIL 296_ KPASA 301_ HSPTQ 306_ VRSRG 311_ KSLSP 316_ RRRQA 321_ SPPRR 326_ LGRRE 331_ KSPAL 336_ PEKKV 341_ ADLST 346_LNEVG
1: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911)