Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A)
1_MSPWS 6_ WFLLQ 11_ TLCLL 16_ PTGAA 21_ SRRGA 26_ PGTAN 31_ CELKP 36_ QQSEL 41_ NSFLW 46_ TIKRD 51_ PPSYF 56_ FGTIH 61_ VPYTR 66_ VWDFI 71_ PDNSK 76_ EAFLQ 81_ SSIVY 86_ FELDL 91_ TDPYT 96_ ISALT 101_ SCQML 106_ PQGEN 111_ LQDVL 116_ PRDIY 121_ CRLKR 126_ HLEYV 131_ KLMMP 136_ LWMTP 141_ DQRGK 146_ GLYAD 151_ YLFNA 156_ IAGNW 161_ ERKRP 166_ VWVML 171_ MVNSL 176_ TEVDI 181_ KSRGV 186_ PVLDL 191_ FLAQE 196_ AERLR 201_ KQTGA 206_ VEKVE 211_ EQCHP 216_ LNGLN 221_ FSQVI 226_ FALNQ 231_ TLLQQ 236_ ESLRA 241_ GSLQI 246_ PYTTE 251_ DLIKH 256_ YNCGD 261_ LSSVI 266_ LSHDS 271_ SQVPN 276_ FINAT 281_ LPPQE 286_ RITAQ 291_ EIDSY 296_ LRREL 301_ IYKRN 306_ ERIGK 311_ RVKAL 316_ LEEFP 321_ DKGFF 326_ FAFGA 331_ GHFMG 336_ NNTVL 341_ DVLRR 346_ EGYEV 351_ EHAPA 356_ GRPIH 361_ KGKSK 366_ KTSTR 371_ PTLST 376_ IFAPK 381_ VPTLE 386_ VPAPE 391_ AVSSG 396_ HSTLP 401_ PLVSR 406_ PGSAD 411_ TPSEA 416_ EQRFR 421_ KKRRR 426_ SQRRP 431_ RLRQF 436_ SDLWV 441_ RLEES 446_ DIVPQ 451_ LQVPV 456_ LDRHI 461_ STELR 466_ LPRRG 471_ HSHHS 476_ QMVAS 481_ SACLS 486_ LWTPV 491_ FWVLV 496_LAFQT
1: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation