Leucine zipper protein 1
1_MAEFT 6_ SYKET 11_ ASSRH 16_ LRFKL 21_ QSLSR 26_ RLDEL 31_ EEATK 36_ NLQKA 41_ EDELL 46_ DLQDK 51_ VIQAE 56_ GSNSS 61_ MLAEI 66_ EVLRQ 71_ RVLRI 76_ EGKDE 81_ EIKRA 86_ EDLCR 91_ LMKEK 96_ LEEEE 101_ NLTRE 106_ LKSEI 111_ ERLQK 116_ RMAEL 121_ EKLEE 126_ AFSRS 131_ KNDCT 136_ QLCLS 141_ LNEER 146_ NLTKK 151_ ISSEL 156_ EMLRV 161_ KVKEL 166_ ESSED 171_ RLDKT 176_ EQSLA 181_ SELEK 186_ LKSLT 191_ LSFVS 196_ ERKYL 201_ NEKEK 206_ ENEKL 211_ IKELT 216_ QKLEQ 221_ NKKMN 226_ RDYTR 231_ NASNL 236_ ERNDL 241_ RIEDG 246_ ISSTL 251_ PSKES 256_ RRKGG 261_ LDYLK 266_ QVENE 271_ TRNKS 276_ ENEKN 281_ RNQED 286_ NKVKD 291_ LNQEI 296_ EKLKT 301_ QIKHF 306_ ESLEE 311_ ELKKM 316_ KSKNN 321_ DLQDN 326_ YLSEQ 331_ NKNKL 336_ LASQL 341_ EEIKL 346_ QIKKQ 351_ KELEN 356_ GEVEG 361_ EDAFL 366_ SSKGR 371_ HERTK 376_ FRGHG 381_ SEASV 386_ SKHTA 391_ RELSP 396_ QHKRE 401_ RLRNR 406_ EFALN 411_ NENYS 416_ LSNRQ 421_ VSSPS 426_ FTNRR 431_ AAKAS 436_ HMGVS 441_ TDSGT 446_ QETKK 451_ TEDRF 456_ VPGSS 461_ QSEGK 466_ KSREQ 471_ PSVLS 476_ RYPPA 481_ AQEHS 486_ KAWKG 491_ TSKPG 496_ TESGL 501_ KGKVE 506_ KTTRT 511_ FSDTT 516_ HGSVP 521_ SDPLG 526_ RADKA 531_ SDTSS 536_ ETVFG 541_ KRGHV 546_ LGNGS 551_ QVTQA 556_ ANSGC 561_ SKAIG 566_ ALASS 571_ RRSSS 576_ EGLSK 581_ GKKAA 586_ NGLEA 591_ DNSCP 596_ NSKAP 601_ VLSKY 606_ PYSCR 611_ SQENI 616_ LQGFS 621_ TSHKE 626_ GVNQP 631_ AAVVM 636_ EDSSP 641_ HEALR 646_ CRVIK 651_ SSGRE 656_ KPDSD 661_ DDLDI 666_ ASLVT 671_ AKLVN 676_ TTITP 681_ EPEPK 686_ PQPNS 691_ REKAK 696_ TRGAP 701_ RTSLF 706_ ENDKD 711_ AGMEN 716_ ESVKS 721_ VRAST 726_ NTMEL 731_ PDTNG 736_ AGVKS 741_ QRPFS 746_ PREAL 751_ RSRAI 756_ IKPVI 761_ VDKDV 766_ KKIMG 771_ GSGTE 776_ TTLEK 781_ QKPVS 786_ KPGPN 791_ KVTSS 796_ ITIYP 801_ SDSSS 806_ PRAAP 811_ GEALR 816_ ERHTS 821_ TSNIQ 826_ VGLAE 831_ LTSVS 836_ NHVSS 841_ PFELS 846_ IHKHD 851_ ITLQL 856_ AEAER 861_ MADGP 866_ LKDRP 871_ ETVVS 876_ RSSII 881_ IKPSD 886_ PVERN 891_ SHAPP 896_ AETIR 901_ WKSHS 906_ APSEV 911_ GFSDA 916_ RHVTV 921_ RNAWK 926_ SRRDL 931_ KSLED 936_ PPTRI 941_ GKNVE 946_ STNSN 951_ AYTQR 956_ SSTDF 961_ SELEQ 966_ PRSCL 971_ FEQGT 976_ RRVGP 981_ SSGDA 986_ PEPSS 991_ RRTQS 996_ SLTVS 1001_ EVLTR 1006_ RNRVG 1011_ DTITV 1016_ AAWNH 1021_ SASME 1026_ EEGED 1031_ CTLSV 1036_ YRQLH 1041_ NSLDP 1046_ SELPG 1051_ KQGLP 1056_ ESGRV 1061_ RAEER 1066_ LRPTR 1071_PCAEE
1: F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity)