Kelch repeat and BTB domain-containing protein 6
1_MQSRE 6_ DAPRS 11_ RRLAS 16_ PRGGK 21_ RPKKI 26_ HKPTV 31_ SAFFT 36_ GPEEL 41_ KDTAH 46_ SAALL 51_ AQLKS 56_ FYDAR 61_ LLCDV 66_ TIEVV 71_ TPGSG 76_ PGTGR 81_ LFPCN 86_ RNVLA 91_ AACPY 96_ FKSMF 101_ TGGMY 106_ ESQQA 111_ SVTMH 116_ DVDAE 121_ SFEVL 126_ VDYCY 131_ TGRVS 136_ LSEAN 141_ VERLY 146_ AASDM 151_ LQLEY 156_ VREAC 161_ ASFLA 166_ RRLDL 171_ TNCTA 176_ ILKFA 181_ DAFGH 186_ RKLRS 191_ QAQSY 196_ IAQNF 201_ KQLSH 206_ MGSIR 211_ EETLA 216_ DLTLA 221_ QLLAV 226_ LRLDS 231_ LDVES 236_ EQTVC 241_ HVAVQ 246_ WLEAA 251_ PKERG 256_ PSAAE 261_ VFKCV 266_ RWMHF 271_ TEEDQ 276_ DYLEG 281_ LLTKP 286_ IVKKY 291_ CLDVI 296_ EGALQ 301_ MRYGD 306_ LLYKS 311_ LVPVP 316_ NSSSS 321_ SSSSN 326_ SLVSA 331_ AENPP 336_ QRLGM 341_ CAKEM 346_ VIFFG 351_ HPRDP 356_ FLCCD 361_ PYSGD 366_ LYKVP 371_ SPLTC 376_ LAHTR 381_ TVTTL 386_ AVCIS 391_ PDHDI 396_ YLAAQ 401_ PRTDL 406_ WVYKP 411_ AQNSW 416_ QQLAD 421_ RLLCR 426_ EGMDV 431_ AYLNG 436_ YIYIL 441_ GGRDP 446_ ITGVK 451_ LKEVE 456_ CYNVK 461_ RNQWA 466_ LVAPL 471_ PHSFL 476_ SFDLM 481_ VIRDY 486_ LYALN 491_ SKRMF 496_ CYDPS 501_ HNMWL 506_ KCVSL 511_ KRNDF 516_ QEACV 521_ FNEEI 526_ YCICD 531_ IPVMK 536_ VYNPV 541_ RAEWR 546_ QMNNI 551_ PLVSE 556_ TNNYR 561_ IIKHG 566_ QKLLL 571_ ITSRT 576_ PQWKK 581_ NRVTV 586_ YEYDI 591_ RGDQW 596_ INIGT 601_ TLGLL 606_ QFDSN 611_ FFCLS 616_ ARVYP 621_ SCLEP 626_ GQSFL 631_ TEEEE 636_ IPSES 641_ STEWD 646_ LGGFS 651_ EPDSE 656_ SGSSS 661_ SLSDD 666_DFWVR
1: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205)