Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]
1_MSKLR 6_ MVLLE 11_ DSGSA 16_ DFRRH 21_ FVNLS 26_ PFTIT 31_ VVLLL 36_ SACFV 41_ TSSLG 46_ GTDKE 51_ LRLVD 56_ GENKC 61_ SGRVE 66_ VKVQE 71_ EWGTV 76_ CNNGW 81_ SMEAV 86_ SVICN 91_ QLGCP 96_ TAIKA 101_ PGWAN 106_ SSAGS 111_ GRIWM 116_ DHVSC 121_ RGNES 126_ ALWDC 131_ KHDGW 136_ GKHSN 141_ CTHQQ 146_ DAGVT 151_ CSDGS 156_ NLEMR 161_ LTRGG 166_ NMCSG 171_ RIEIK 176_ FQGRW 181_ GTVCD 186_ DNFNI 191_ DHASV 196_ ICRQL 201_ ECGSA 206_ VSFSG 211_ SSNFG 216_ EGSGP 221_ IWFDD 226_ LICNG 231_ NESAL 236_ WNCKH 241_ QGWGK 246_ HNCDH 251_ AEDAG 256_ VICSK 261_ GADLS 266_ LRLVD 271_ GVTEC 276_ SGRLE 281_ VRFQG 286_ EWGTI 291_ CDDGW 296_ DSYDA 301_ AVACK 306_ QLGCP 311_ TAVTA 316_ IGRVN 321_ ASKGF 326_ GHIWL 331_ DSVSC 336_ QGHEP 341_ AIWQC 346_ KHHEW 351_ GKHYC 356_ NHNED 361_ AGVTC 366_ SDGSD 371_ LELRL 376_ RGGGS 381_ RCAGT 386_ VEVEI 391_ QRLLG 396_ KVCDR 401_ GWGLK 406_ EADVV 411_ CRQLG 416_ CGSAL 421_ KTSYQ 426_ VYSKI 431_ QATNT 436_ WLFLS 441_ SCNGN 446_ ETSLW 451_ DCKNW 456_ QWGGL 461_ TCDHY 466_ EEAKI 471_ TCSAH 476_ REPRL 481_ VGGDI 486_ PCSGR 491_ VEVKH 496_ GDTWG 501_ SICDS 506_ DFSLE 511_ AASVL 516_ CRELQ 521_ CGTVV 526_ SILGG 531_ AHFGE 536_ GNGQI 541_ WAEEF 546_ QCEGH 551_ ESHLS 556_ LCPVA 561_ PRPEG 566_ TCSHS 571_ RDVGV 576_ VCSRY 581_ TEIRL 586_ VNGKT 591_ PCEGR 596_ VELKT 601_ LGAWG 606_ SLCNS 611_ HWDIE 616_ DAHVL 621_ CQQLK 626_ CGVAL 631_ STPGG 636_ ARFGK 641_ GNGQI 646_ WRHMF 651_ HCTGT 656_ EQHMG 661_ DCPVT 666_ ALGAS 671_ LCPSE 676_ QVASV 681_ ICSGN 686_ QSQTL 691_ SSCNS 696_ SSLGP 701_ TRPTI 706_ PEESA 711_ VACIE 716_ SGQLR 721_ LVNGG 726_ GRCAG 731_ RVEIY 736_ HEGSW 741_ GTICD 746_ DSWDL 751_ SDAHV 756_ VCRQL 761_ GCGEA 766_ INATG 771_ SAHFG 776_ EGTGP 781_ IWLDE 786_ MKCNG 791_ KESRI 796_ WQCHS 801_ HGWGQ 806_ QNCRH 811_ KEDAG 816_ VICSE 821_ FMSLR 826_ LTSEA 831_ SREAC 836_ AGRLE 841_ VFYNG 846_ AWGTV 851_ GKSSM 856_ SETTV 861_ GVVCR 866_ QLGCA 871_ DKGKI 876_ NPASL 881_ DKAMS 886_ IPMWV 891_ DNVQC 896_ PKGPD 901_ TLWQC 906_ PSSPW 911_ EKRLA 916_ SPSEE 921_ TWITC 926_ DNKIR 931_ LQEGP 936_ TSCSG 941_ RVEIW 946_ HGGSW 951_ GTVCD 956_ DSWDL 961_ DDAQV 966_ VCQQL 971_ GCGPA 976_ LKAFK 981_ EAEFG 986_ QGTGP 991_ IWLNE 996_ VKCKG 1001_ NESSL 1006_ WDCPA 1011_ RRWGH 1016_ SECGH 1021_ KEDAA 1026_ VNCTD 1031_ ISVQK 1036_ TPQKA 1041_ TTGRS 1046_ SRQSS 1051_ FIAVG 1056_ ILGVV 1061_ LLAIF 1066_ VALFF 1071_ LTKKR 1076_ RQRQR 1081_ LAVSS 1086_ RGENL 1091_ VHQIQ 1096_ YREMN 1101_ SCLNA 1106_ DDLDL 1111_ MNSSE 1116_ NSHES 1121_ ADFSA 1126_ AELIS 1131_ VSKFL 1136_ PISGM 1141_ EKEAI 1146_ LSHTE 1151_KENGN
1: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells
2: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions