Serine incorporator 5
1_MSAQC 6_ CAGQL 11_ ACCCG 16_ SAGCS 21_ LCCDC 26_ CPRIR 31_ QSLST 36_ RFMYA 41_ LYFIL 46_ VVVLC 51_ CIMMS 56_ TTVAH 61_ KMKEH 66_ IPFFE 71_ DMCKG 76_ IKAGD 81_ TCEKL 86_ VGYSA 91_ VYRVC 96_ FGMAC 101_ FFFIF 106_ CLLTL 111_ KINNS 116_ KSCRA 121_ HIHNG 126_ FWFFK 131_ LLLLG 136_ AMCSG 141_ AFFIP 146_ DQDTF 151_ LNAWR 156_ YVGAV 161_ GGFLF 166_ IGIQL 171_ LLLVE 176_ FAHKW 181_ NKNWT 186_ AGTAS 191_ NKLWY 196_ ASLAL 201_ VTLIM 206_ YSIAT 211_ GGLVL 216_ MAVFY 221_ TQKDS 226_ CMENK 231_ ILLGV 236_ NGGLC 241_ LLISL 246_ VAISP 251_ WVQNR 256_ QPHSG 261_ LLQSG 266_ VISCY 271_ VTYLT 276_ FSALS 281_ SKPAE 286_ VVLDE 291_ HGKNV 296_ TICVP 301_ DFGQD 306_ LYRDE 311_ NLVTI 316_ LGTSL 321_ LIGCI 326_ LYSCL 331_ TSTTR 336_ SSSDA 341_ LQGRY 346_ AAPEL 351_ EIARC 356_ CFCFS 361_ PGGED 366_ TEEQQ 371_ PGKEG 376_ PRVIY 381_ DEKKG 386_ TVYIY 391_ SYFHF 396_ VFFLA 401_ SLYVM 406_ MTVTN 411_ WFNHV 416_RSAFH
1: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity)