Zinc finger protein 410 (Another partner for ARF 1)
1_MLSDE 6_ LESKP 11_ ELLVQ 16_ FVQNT 21_ SIPLG 26_ QGLVE 31_ SEAKD 36_ ITCLS 41_ LLPVT 46_ EASEC 51_ SRLML 56_ PDDTT 61_ NHSNS 66_ SKEVP 71_ SSAVL 76_ RSLRV 81_ NVGPD 86_ GEETR 91_ AQTVQ 96_ KSPEF 101_ LSTSE 106_ SSSLL 111_ QDLQP 116_ SDSTS 121_ FILLN 126_ LTRAG 131_ LGSSA 136_ EHLVF 141_ VQDEA 146_ EDSGN 151_ DFLSS 156_ ESTDS 161_ SIPWF 166_ LRVQE 171_ LAHDS 176_ LIAAT 181_ RAQLA 186_ KNAKT 191_ SSNGE 196_ NVHLG 201_ SGDGQ 206_ SKDSG 211_ PLPQV 216_ EKKLK 221_ CTVEG 226_ CDRTF 231_ VWPAH 236_ FKYHL 241_ KTHRN 246_ DRSFI 251_ CPAEG 256_ CGKSF 261_ YVLQR 266_ LKVHM 271_ RTHNG 276_ EKPFM 281_ CHESG 286_ CGKQF 291_ TTAGN 296_ LKNHR 301_ RIHTG 306_ EKPFL 311_ CEAQG 316_ CGRSF 321_ AEYSS 326_ LRKHL 331_ VVHSG 336_ EKPHQ 341_ CQVCG 346_ KTFSQ 351_ SGSRN 356_ VHMRK 361_ HHLQL 366_ GAAGS 371_ QEQEQ 376_ TAEPL 381_ MGSSL 386_ LEEAS 391_ VPSKN 396_ LVSMN 401_ SQPSL 406_ GGESL 411_ NLPNT 416_ NSILG 421_ VDDEV 426_ LAEGS 431_ PRSLS 436_ SVPDV 441_ THHLV 446_ TMQSG 451_ RQSYE 456_ VSVLT 461_ AVNPQ 466_ ELLNQ 471_GDLTE
1: Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33301730, PubMed:33859416). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33301730, PubMed:33859416). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33301730, PubMed:33859416)