Multidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2)
1_MDSLQ 6_ DTVAL 11_ DHGGC 16_ CPALS 21_ RLVPR 26_ GFGTE 31_ MWTLF 36_ ALSGP 41_ LFLFQ 46_ VLTFM 51_ IYIVS 56_ TVFCG 61_ HLGKV 66_ ELASV 71_ TLAVA 76_ FVNVC 81_ GVSVG 86_ VGLSS 91_ ACDTL 96_ MSQSF 101_ GSPNK 106_ KHVGV 111_ ILQRG 116_ ALVLL 121_ LCCLP 126_ CWALF 131_ LNTQH 136_ ILLLF 141_ RQDPD 146_ VSRLT 151_ QDYVM 156_ IFIPG 161_ LPVIF 166_ LYNLL 171_ AKYLQ 176_ NQGWL 181_ KGQEE 186_ ESPFQ 191_ TPGLS 196_ ILHPS 201_ HSHLS 206_ RASFH 211_ LFQKI 216_ TWPQV 221_ LSGVV 226_ GNCVN 231_ GVANY 236_ ALVSV 241_ LNLGV 246_ RGSAY 251_ ANIIS 256_ QFAQT 261_ VFLLL 266_ YIVLK 271_ KLHLE 276_ TWAGW 281_ SSQCL 286_ QDWGP 291_ FFSLA 296_ VPSML 301_ MICVE 306_ WWAYE 311_ IGSFL 316_ MGLLS 321_ VVDLS 326_ AQAVI 331_ YEVAT 336_ VTYMI 341_ PLGLS 346_ IGVCV 351_ RVGMA 356_ LGAAD 361_ TVQAK 366_ RSAVS 371_ GVLSI 376_ VGISL 381_ VLGTL 386_ ISILK 391_ NQLGH 396_ IFTND 401_ EDVIA 406_ LVSQV 411_ LPVYS 416_ VFHVF 421_ EAICC 426_ VYGGV 431_ LRGTG 436_ KQAFG 441_ AAVNA 446_ ITYYI 451_ IGLPL 456_ GILLT 461_ FVVRM 466_ RIMGL 471_ WLGML 476_ ACVFL 481_ ATAAF 486_ VAYTA 491_ RLDWK 496_ LAAEE 501_ AKKHS 506_ GRQQQ 511_ QRAES 516_ TATRP 521_ GPEKA 526_ VLSSV 531_ ATGSS 536_ PGITL 541_ TTYSR 546_ SECHV 551_ DFFRT 556_ PEEAH 561_ ALSAP 566_ TSRLS 571_ VKQLV 576_ IRRGA 581_ ALGAA 586_ SATLM 591_ VGLTV 596_RILAT
1: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney
2: Non-functional protein