Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36)
1_MDRFV 6_ WTSGL 11_ LEINE 16_ TLVIQ 21_ QRGVR 26_ IYDGE 31_ EKIKF 36_ DAGTL 41_ LLSTH 46_ RLIWR 51_ DQKNH 56_ ECCMA 61_ ILLSQ 66_ IVFIE 71_ EQAAG 76_ IGKSA 81_ KIVVH 86_ LHPAP 91_ PNKEP 96_ GPFQS 101_ SKNSY 106_ IKLSF 111_ KEHGQ 116_ IEFYR 121_ RLSEE 126_ MTQRR 131_ WENMP 136_ VSQSL 141_ QTNRG 146_ PQPGR 151_ IRAVG 156_ IVGIE 161_ RKLEE 166_ KRKET 171_ DKNIS 176_ EAFED 181_ LSKLM 186_ IKAKE 191_ MVELS 196_ KSIAN 201_ KIKDK 206_ QGDIT 211_ EDETI 216_ RFKSY 221_ LLSMG 226_ IANPV 231_ TRETY 236_ GSGTQ 241_ YHMQL 246_ AKQLA 251_ GILQV 256_ PLEER 261_ GGIMS 266_ LTEVY 271_ CLVNR 276_ ARGME 281_ LLSPE 286_ DLVNA 291_ CKMLE 296_ ALKLP 301_ LRLRV 306_ FDSGV 311_ MVIEL 316_ QSHKE 321_ EEMVA 326_ SALET 331_ VSEKG 336_ SLTSE 341_ EFAKL 346_ VGMSV 351_ LLAKE 356_ RLLLA 361_ EKMGH 366_ LCRDD 371_ SVEGL 376_ RFYPN 381_LFMTQ
1: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3