Tax1-binding protein 1 (TRAF6-binding protein)
1_MTSFQ 6_ EVPLQ 11_ TSNFA 16_ HVIFQ 21_ NVAKS 26_ YLPNA 31_ HLECH 36_ YTLTP 41_ YIHPH 46_ PKDWV 51_ GIFKV 56_ GWSTA 61_ RDYYT 66_ FLWSP 71_ MPEHY 76_ VEGST 81_ VNCVL 86_ AFQGY 91_ YLPND 96_ DGEFY 101_ QFCYV 106_ THKGE 111_ IRGAS 116_ TPFQF 121_ RASSP 126_ VEELL 131_ TMEDE 136_ GNSDM 141_ LVVTT 146_ KAGLL 151_ ELKIE 156_ KTMKE 161_ KEELL 166_ KLIAV 171_ LEKET 176_ AQLRE 181_ QVGRM 186_ ERELN 191_ HEKER 196_ CDQLQ 201_ AEQKG 206_ LTEVT 211_ QSLKM 216_ ENEEF 221_ KKRFS 226_ DATSK 231_ AHQLE 236_ EDIVS 241_ VTHKA 246_ IEKET 251_ ELDSL 256_ KDKLK 261_ KAQHE 266_ REQLE 271_ CQLKT 276_ EKDEK 281_ ELYKV 286_ HLKNT 291_ EIENT 296_ KLMSE 301_ VQTLK 306_ NLDGN 311_ KESVI 316_ THFKE 321_ EIGRL 326_ QLCLA 331_ EKENL 336_ QRTFL 341_ LTTSS 346_ KEDTC 351_ FLKEQ 356_ LRKAE 361_ EQVQA 366_ TRQEV 371_ VFLAK 376_ ELSDA 381_ VNVRD 386_ RTMAD 391_ LHTAR 396_ LENEK 401_ VKKQL 406_ ADAVA 411_ ELKLN 416_ AMKKD 421_ QDKTD 426_ TLEHE 431_ LRREV 436_ EDLKL 441_ RLQMA 446_ ADHYK 451_ EKFKE 456_ CQRLQ 461_ KQINK 466_ LSDQS 471_ ANNNN 476_ VFTKK 481_ TGNQQ 486_ KVNDA 491_ SVNTD 496_ PATSA 501_ STVDV 506_ KPSPS 511_ AAEAD 516_ FDIVT 521_ KGQVC 526_ EMTKE 531_ IADKT 536_ EKYNK 541_ CKQLL 546_ QDEKA 551_ KCNKY 556_ ADELA 561_ KMELK 566_ WKEQV 571_ KIAEN 576_ VKLEL 581_ AEVQD 586_ NYKEL 591_ KRSLE 596_ NPAER 601_ KMEGQ 606_ NSQSP 611_ QCFKT 616_ CSEQN 621_ GYVLT 626_ LSNAQ 631_ PVLQY 636_ GNPYA 641_ SQETR 646_ DGADG 651_ AFYPD 656_ EIQRP 661_ PVRVP 666_ SWGLE 671_ DNVVC 676_ SQPAR 681_ NFSRP 686_ DGLED 691_ SEDSK 696_ EDENV 701_ PTAPD 706_ PPSQH 711_ LRGHG 716_ TGFCF 721_ DSSFD 726_ VHKKC 731_ PLCEL 736_ MFPPN 741_ YDQSK 746_ FEEHV 751_ ESHWK 756_ VCPMC 761_ SEQFP 766_ PDYDQ 771_ QVFER 776_ HVQTH 781_FDQNV
1: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289)