Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)
1_MAERG 6_ RLGLP 11_ GAPGA 16_ LNTPV 21_ PMNLF 26_ ATWEV 31_ DGSSP 36_ SCVPR 41_ LCSLT 46_ LKKLV 51_ VFKEL 56_ EKELI 61_ SVVIA 66_ VKMQG 71_ SKRIL 76_ RSHEI 81_ VLPPS 86_ GQVET 91_ DLALT 96_ FSLQY 101_ PHFLK 106_ REGNK 111_ LQIML 116_ QRRKR 121_ YKNRT 126_ ILGYK 131_ TLAAG 136_ SISMA 141_ EVMQH 146_ PSEGG 151_ QVLSL 156_ CSSIK 161_ EAPVK 166_ AAEIW 171_ IASLS 176_ SQPID 181_ HEDST 186_ MQAGP 191_ KAKST 196_ DNYSE 201_ EEYES 206_ FSSEQ 211_ EASDD 216_ AVQGQ 221_ DLDED 226_ DFDVG 231_ KPKKQ 236_ RRSIV 241_ RTTSM 246_ TRQQN 251_ FKQKV 256_ VALLR 261_ RFKVS 266_ DEVLD 271_ SEQDP 276_ AEHIP 281_ EAEED 286_ LDLLY 291_ DTLDM 296_ EHPSD 301_ SGPDM 306_ EDDDS 311_ VLSTP 316_ KPKLR 321_ PYFEG 326_ LSHSS 331_ SQTEI 336_ GSIHS 341_ ARSHK 346_ EPPSP 351_ ADVPE 356_ KTRSL 361_ GGRQP 366_ SDSVS 371_ DTVAL 376_ GVPGP 381_ REHPG 386_ QPEDS 391_ PEAEA 396_ STLDV 401_ FTERL 406_ PPSGR 411_ ITKTE 416_ SLVIP 421_ STRSE 426_ GKQAG 431_ RRGRS 436_ TSLKE 441_ RQAAR 446_ PQNER 451_ ANSLD 456_ NERCP 461_ DARSQ 466_ LQIPR 471_ KTVYD 476_ QLNHI 481_ LISDD 486_ QLPEN 491_ IILVN 496_ TSDWQ 501_ GQFLS 506_ DVLQR 511_ HTLPV 516_ VCTCS 521_ PADVQ 526_ AAFST 531_ IVSRI 536_ QRYCN 541_ CNSQP 546_ PTPVK 551_ IAVAG 556_ AQHYL 561_ SAILR 566_ LFVEQ 571_ LSHKT 576_ PDWLG 581_ YMRFL 586_ VIPLG 591_ SHPVA 596_ RYLGS 601_ VDYRY 606_ NNFFQ 611_ DLAWR 616_ DLFNK 621_ LEAQS 626_ AVQDT 631_ PDIVS 636_ RITQY 641_ IAGAN 646_ CAHQL 651_ PIAEA 656_ MLTYK 661_ QKSPD 666_ EESSQ 671_ KFIPF 676_ VGVVK 681_ VGIVE 686_ PSSAT 691_ SGDSD 696_ DAAPS 701_ GSGTL 706_ SSTPP 711_ SASPA 716_ AKEAS 721_ PTPPS 726_ SPSVS 731_ GGLSS 736_ PSQGV 741_ GAELM 746_ GLQVD 751_ YWTAA 756_ QPADR 761_ KRDAE 766_ KKDLP 771_ VTKNT 776_ LKCTF 781_ RSLQV 786_ SRLPS 791_ SGEAA 796_ ATPTM 801_ SMTVV 806_ TKEKN 811_ KKVMF 816_ LPKKA 821_ KDKDV 826_ ESKSQ 831_ CIEGI 836_ SRLIC 841_ TARQQ 846_ QNMLR 851_ VLIDG 856_ VECSD 861_ VKFFQ 866_ LAAQW 871_ SSHVK 876_ HFPIC 881_IFGHS
1: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments