Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
1_MASAS 6_ YHISN 11_ LLEKM 16_ TSSDK 21_ DFRFM 26_ ATNDL 31_ MTELQ 36_ KDSIK 41_ LDDDS 46_ ERKVV 51_ KMILK 56_ LLEDK 61_ NGEVQ 66_ NLAVK 71_ CLGPL 76_ VSKVK 81_ EYQVE 86_ TIVDT 91_ LCTNM 96_ LSDKE 101_ QLRDI 106_ SSIGL 111_ KTVIG 116_ ELPPA 121_ SSGSA 126_ LAANV 131_ CKKIT 136_ GRLTS 141_ AIAKQ 146_ EDVSV 151_ QLEAL 156_ DIMAD 161_ MLSRQ 166_ GGLLV 171_ NFHPS 176_ ILTCL 181_ LPQLT 186_ SPRLA 191_ VRKRT 196_ IIALG 201_ HLVMS 206_ CGNIV 211_ FVDLI 216_ EHLLS 221_ ELSKN 226_ DSMST 231_ TRTYI 236_ QCIAA 241_ ISRQA 246_ GHRIG 251_ EYLEK 256_ IIPLV 261_ VKFCN 266_ VDDDE 271_ LREYC 276_ IQAFE 281_ SFVRR 286_ CPKEV 291_ YPHVS 296_ TIINI 301_ CLKYL 306_ TYDPN 311_ YNYDD 316_ EDEDE 321_ NAMDA 326_ DGGDD 331_ DDQGS 336_ DDEYS 341_ DDDDM 346_ SWKVR 351_ RAAAK 356_ CLDAV 361_ VSTRH 366_ EMLPE 371_ FYKTV 376_ SPALI 381_ SRFKE 386_ REENV 391_ KADVF 396_ HAYLS 401_ LLKQT 406_ RPVQS 411_ WLCDP 416_ DAMEQ 421_ GETPL 426_ TMLQS 431_ QVPNI 436_ VKALH 441_ KQMKE 446_ KSVKT 451_ RQCCF 456_ NMLTE 461_ LVNVL 466_ PGALT 471_ QHIPV 476_ LVPGI 481_ IFSLN 486_ DKSSS 491_ SNLKI 496_ DALSC 501_ LYVIL 506_ CNHSP 511_ QVFHP 516_ HVQAL 521_ VPPVV 526_ ACVGD 531_ PFYKI 536_ TSEAL 541_ LVTQQ 546_ LVKVI 551_ RPLDQ 556_ PSSFD 561_ ATPYI 566_ KDLFT 571_ CTIKR 576_ LKAAD 581_ IDQEV 586_ KERAI 591_ SCMGQ 596_ IICNL 601_ GDNLG 606_ SDLPN 611_ TLQIF 616_ LERLK 621_ NEITR 626_ LTTVK 631_ ALTLI 636_ AGSPL 641_ KIDLR 646_ PVLGE 651_ GVPIL 656_ ASFLR 661_ KNQRA 666_ LKLGT 671_ LSALD 676_ ILIKN 681_ YSDSL 686_ TAAMI 691_ DAVLD 696_ ELPPL 701_ ISESD 706_ MHVSQ 711_ MAISF 716_ LTTLA 721_ KVYPS 726_ SLSKI 731_ SGSIL 736_ NELIG 741_ LVRSP 746_ LLQGG 751_ ALSAM 756_ LDFFQ 761_ ALVVT 766_ GTNNL 771_ GYMDL 776_ LRMLT 781_ GPVYS 786_ QSTAL 791_ THKQS 796_ YYSIA 801_ KCVAA 806_ LTRAC 811_ PKEGP 816_ AVVGQ 821_ FIQDV 826_ KNSRS 831_ TDSIR 836_ LLALL 841_ SLGEV 846_ GHHID 851_ LSGQL 856_ ELKSV 861_ ILEAF 866_ SSPSE 871_ EVKSA 876_ ASYAL 881_ GSISV 886_ GNLPE 891_ YLPFV 896_ LQEIT 901_ SQPKR 906_ QYLLL 911_ HSLKE 916_ IISSA 921_ SVVGL 926_ KPYVE 931_ NIWAL 936_ LLKHC 941_ ECAEE 946_ GTRNV 951_ VAECL 956_ GKLTL 961_ IDPET 966_ LLPRL 971_ KGYLI 976_ SGSSY 981_ ARSSV 986_ VTAVK 991_ FTISD 996_ HPQPI 1001_ DPLLK 1006_ NCIGD 1011_ FLKTL 1016_ EDPDL 1021_ NVRRV 1026_ ALVTF 1031_ NSAAH 1036_ NKPSL 1041_ IRDLL 1046_ DTVLP 1051_ HLYNE 1056_ TKVRK 1061_ ELIRE 1066_ VEMGP 1071_ FKHTV 1076_ DDGLD 1081_ IRKAA 1086_ FECMY 1091_ TLLDS 1096_ CLDRL 1101_ DIFEF 1106_ LNHVE 1111_ DGLKD 1116_ HYDIK 1121_ MLTFL 1126_ MLVRL 1131_ STLCP 1136_ SAVLQ 1141_ RLDRL 1146_ VEPLR 1151_ ATCTT 1156_ KVKAN 1161_ SVKQE 1166_ FEKQD 1171_ ELKRS 1176_ AMRAV 1181_ AALLT 1186_ IPEAE 1191_ KSPLM 1196_ SEFQS 1201_ QISSN 1206_ PELAA 1211_ IFESI 1216_ QKDSS 1221_STNLE
1: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes