Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2)
1_MERSP 6_ PQSPG 11_ PGKAG 16_ DAPNR 21_ RSGHV 26_ RGARV 31_ LSPPG 36_ RRARL 41_ SSPGP 46_ SRSSE 51_ AREEL 56_ RRHLV 61_ GLIER 66_ SRVVI 71_ FSKSY 76_ CPHST 81_ RVKEL 86_ FSSLG 91_ VECNV 96_ LELDQ 101_ VDDGA 106_ RVQEV 111_ LSEIT 116_ NQKTV 121_ PNIFV 126_ NKVHV 131_ GGCDQ 136_ TFQAY 141_ QSGLL 146_ QKLLQ 151_ EDLAY 156_ DYDLI 161_ IIGGG 166_ SGGLS 171_ CAKEA 176_ AILGK 181_ KVMVL 186_ DFVVP 191_ SPQGT 196_ SWGLG 201_ GTCVN 206_ VGCIP 211_ KKLMH 216_ QAALL 221_ GQALC 226_ DSRKF 231_ GWEYN 236_ QQVRH 241_ NWETM 246_ TKAIQ 251_ NHISS 256_ LNWGY 261_ RLSLR 266_ EKAVA 271_ YVNSY 276_ GEFVE 281_ HHKIK 286_ ATNKK 291_ GQETY 296_ YTAAQ 301_ FVIAT 306_ GERPR 311_ YLGIQ 316_ GDKEY 321_ CITSD 326_ DLFSL 331_ PYCPG 336_ KTLVV 341_ GASYV 346_ ALECA 351_ GFLAG 356_ FGLDV 361_ TVMVR 366_ SILLR 371_ GFDQE 376_ MAEKV 381_ GSYME 386_ QHGVK 391_ FLRKF 396_ IPVMV 401_ QQLEK 406_ GSPGK 411_ LKVLA 416_ KSTEG 421_ TETIE 426_ GVYNT 431_ VLLAI 436_ GRDSC 441_ TRKIG 446_ LEKIG 451_ VKINE 456_ KSGKI 461_ PVNDV 466_ EQTNV 471_ PYVYA 476_ VGDIL 481_ EDKPE 486_ LTPVA 491_ IQSGK 496_ LLAQR 501_ LFGAS 506_ LEKCD 511_ YINVP 516_ TTVFT 521_ PLEYG 526_ CCGLS 531_ EEKAI 536_ EVYKK 541_ ENLEI 546_ YHTLF 551_ WPLEW 556_ TVAGR 561_ ENNTC 566_ YAKII 571_ CNKFD 576_ HDRVI 581_ GFHIL 586_ GPNAG 591_ EVTQG 596_ FAAAM 601_ KCGLT 606_ KQLLD 611_ DTIGI 616_ HPTCG 621_ EVFTT 626_ LEITK 631_ SSGLD 636_ITQKG
1: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)