Reticulophagy regulator 3
1_MAEAE 6_ GVPTT 11_ PGPAS 16_ GSTFR 21_ GRRDV 26_ SGSWE 31_ RDQQV 36_ EAAQR 41_ ALVEV 46_ LGPYE 51_ PLLSR 56_ VQAAL 61_ VWERP 66_ ARSAL 71_ WCLGL 76_ NAAFW 81_ FFALT 86_ SLRLV 91_ FLLAF 96_ GLMII 101_ VCIDQ 106_ WKNKI 111_ WPEIK 116_ VPRPD 121_ ALDNE 126_ SWGFV 131_ HPRLL 136_ SVPEL 141_ CHHVA 146_ EVWVS 151_ GTIFI 156_ RNVLL 161_ FKKQN 166_ PGKFC 171_ LLSCG 176_ ILTFL 181_ AVLGR 186_ YVPGL 191_ LLSYL 196_ MLVTV 201_ MMWPL 206_ AVYHR 211_ LWDRA 216_ YVRLK 221_ PALQR 226_ LDFSV 231_ RGYMM 236_ SKQRE 241_ RQLRR 246_ RALHP 251_ ERAMD 256_ NHSDS 261_ EEELA 266_ AFCPQ 271_ LDDST 276_ VAREL 281_ AITDS 286_ EHSDA 291_ EVSCT 296_ DNGTF 301_ NLSRG 306_ QTPLT 311_ EGSED 316_ LDGHS 321_ DPEES 326_ FARDL 331_ PDFPS 336_ INMDP 341_ AGLDD 346_ EDDTS 351_ IGMPS 356_ LMYRS 361_ PPGAE 366_ EPQAP 371_ PASRD 376_ EAALP 381_ ELLLG 386_ ALPVG 391_ SNLTS 396_ NLASL 401_ VSQGM 406_ IQLAL 411_ SGASQ 416_ PGPSG 421_ APAQR 426_ ATRGF 431_ LRSPS 436_ SDLDT 441_ DAEGD 446_ DFELL 451_ DQSEL 456_ SQLDP 461_ASSRS
1: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720)