Protein Hook homolog 3 (h-hook3) (hHK3)
1_MFSVE 6_ SLERA 11_ ELCES 16_ LLTWI 21_ QTFNV 26_ DAPCQ 31_ TVEDL 36_ TNGVV 41_ MAQVL 46_ QKIDP 51_ AYFDE 56_ NWLNR 61_ IKTEV 66_ GDNWR 71_ LKISN 76_ LKKIL 81_ KGILD 86_ YNHEI 91_ LGQQI 96_ NDFTL 101_ PDVNL 106_ IGEHS 111_ DAAEL 116_ GRMLQ 121_ LILGC 126_ AVNCE 131_ QKQEY 136_ IQAIM 141_ MMEES 146_ VQHVV 151_ MTAIQ 156_ ELMSK 161_ ESPVS 166_ AGNDA 171_ YVDLD 176_ RQLKK 181_ TTEEL 186_ NEALS 191_ AKEEI 196_ AQRCH 201_ ELDMQ 206_ VAALQ 211_ EEKSS 216_ LLAEN 221_ QVLME 226_ RLNQS 231_ DSIED 236_ PNSPA 241_ GRRHL 246_ QLQTQ 251_ LEQLQ 256_ EETFR 261_ LEAAK 266_ DDYRI 271_ RCEEL 276_ EKEIS 281_ ELRQQ 286_ NDELT 291_ TLADE 296_ AQSLK 301_ DEIDV 306_ LRHSS 311_ DKVSK 316_ LEGQV 321_ ESYKK 326_ KLEDL 331_ GDLRR 336_ QVKLL 341_ EEKNT 346_ MYMQN 351_ TVSLE 356_ EELRK 361_ ANAAR 366_ SQLET 371_ YKRQV 376_ VELQN 381_ RLSEE 386_ SKKAD 391_ KLDFE 396_ YKRLK 401_ EKVDS 406_ LQKEK 411_ DRLRT 416_ ERDSL 421_ KETIE 426_ ELRCV 431_ QAQEG 436_ QLTTQ 441_ GLMPL 446_ GSQES 451_ SDSLA 456_ AEIVT 461_ PEIRE 466_ KLIRL 471_ QHENK 476_ MLKLN 481_ QEGSD 486_ NEKIA 491_ LLQSL 496_ LDDAN 501_ LRKNE 506_ LETEN 511_ RLVNQ 516_ RLLEV 521_ QSQVE 526_ ELQKS 531_ LQDQG 536_ SKAED 541_ SVLLK 546_ KKLEE 551_ HLEKL 556_ HEANN 561_ ELQKK 566_ RAIIE 571_ DLEPR 576_ FNNSS 581_ LKIEE 586_ LQEAL 591_ RKKEE 596_ EMKQM 601_ EERYK 606_ KYLEK 611_ AKSVI 616_ RTLDP 621_ KQNQG 626_ AAPEI 631_ QALKN 636_ QLQER 641_ DRLFH 646_ SLEKE 651_ YEKTK 656_ SQREM 661_ EEKYI 666_ VSAWY 671_ NMGMT 676_ LHKKA 681_ AEDRL 686_ ASTGS 691_ GQSFL 696_ ARQRQ 701_ ATSSR 706_ RSYPG 711_HVQPA
1: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997)
2: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking