SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein) (Protein Solo)
1_MEASV 6_ ILPIL 11_ KKKLA 16_ FLSGG 21_ KDRRS 26_ GLILT 31_ IPLCL 36_ EQTNM 41_ DELSV 46_ TLDYL 51_ LSIPS 56_ EKCKA 61_ RGFTV 66_ IVDGR 71_ KSQWN 76_ VVKTV 81_ VVMLQ 86_ NVVPA 91_ EVSLV 96_ CVVKP 101_ DEFWD 106_ KKVTH 111_ FCFWK 116_ EKDRL 121_ GFEVI 126_ LVSAN 131_ KLTRY 136_ IEPCQ 141_ LTEDF 146_ GGSLT 151_ YDHMD 156_ WLNKR 161_ LVFEK 166_ FTKES 171_ TSLLD 176_ ELALI 181_ NNGSD 186_ KGNQQ 191_ EKERS 196_ VDLNF 201_ LPSVD 206_ PETVL 211_ QTGHE 216_ LLSEL 221_ QQRRF 226_ NGSDG 231_ GVSWS 236_ PMDDE 241_ LLAQP 246_ QVMKL 251_ LDSLR 256_ EQYTR 261_ YQEVC 266_ RQRSK 271_ RTQLE 276_ EIQQK 281_ VMQVV 286_ NWLEG 291_ PGSEQ 296_ LRAQW 301_ GIGDS 306_ IRASQ 311_ ALQQK 316_ HEEIE 321_ SQHSE 326_ WFAVY 331_ VELNQ 336_ QIAAL 341_ LNAGD 346_ EEDLV 351_ ELKSL 356_ QQQLS 361_ DVCYR 366_ QASQL 371_ EFRQN 376_ LLQAA 381_ LEFHG 386_ VAQDL 391_ SQQLD 396_ GLLGM 401_ LCVDV 406_ APADG 411_ ASIQQ 416_ TLKLL 421_ EEKLK 426_ SVDVG 431_ LQGLR 436_ EKGQG 441_ LLDQI 446_ SNQAS 451_ WAYGK 456_ DVTIE 461_ NKENV 466_ DHIQG 471_ VMEDM 476_ QLRKQ 481_ RCEDM 486_ VDVRR 491_ LKMLQ 496_ MVQLF 501_ KCEED 506_ AAQAV 511_ EWLSE 516_ LLDAL 521_ LKTHI 526_ RLGDD 531_ AQETK 536_ VLLEK 541_ HRKFV 546_ DVAQS 551_ TYDYG 556_ RQLLQ 561_ ATVVL 566_ CQSLR 571_ CTSRS 576_ SGDTL 581_ PRLNR 586_ VWKQF 591_ TIASE 596_ ERVHR 601_ LEMAI 606_ AFHSN 611_ AEKIL 616_ QDCPE 621_ EPEAI 626_ NDEEQ 631_ FDEIE 636_ AVGKS 641_ LLDRL 646_ TVPVV 651_ YPDGT 656_ EQYFG 661_ SPSDM 666_ ASTAE 671_ NIRDR 676_ MKLVN 681_ LKRQQ 686_ LRHPE 691_MVTTE
1: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1