Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF)
1_MRGGH 6_ KGGRC 11_ ACPRV 16_ IRKVL 21_ AKCGC 26_ CFARG 31_ GRESY 36_ SIAGS 41_ EGSIS 46_ ASAAS 51_ GLAAP 56_ SGPSS 61_ GLSSG 66_ PCSPG 71_ PPGPV 76_ SGLRR 81_ WLDHS 86_ KHCLS 91_ VETEA 96_ DSGQA 101_ GPYEN 106_ WMLEP 111_ ALATG 116_ EELPE 121_ LTLLT 126_ TLLEG 131_ PGDKT 136_ QPPEE 141_ ETLSQ 146_ APESE 151_ EEQKK 156_ KALER 161_ SMYVL 166_ SELVE 171_ TEKMY 176_ VDDLG 181_ QIVEG 186_ YMATM 191_ AAQGV 196_ PESLR 201_ GRDRI 206_ VFGNI 211_ QQIYE 216_ WHRDY 221_ FLQEL 226_ QRCLK 231_ DPDWL 236_ AQLFI 241_ KHERR 246_ LHMYV 251_ VYCQN 256_ KPKSE 261_ HVVSE 266_ FGDSY 271_ FEELR 276_ QQLGH 281_ RLQLN 286_ DLLIK 291_ PVQRI 296_ MKYQL 301_ LLKDF 306_ LKYYN 311_ RAGMD 316_ TADLE 321_ QAVEV 326_ MCFVP 331_ KRCND 336_ MMTLG 341_ RLRGF 346_ EGKLT 351_ AQGKL 356_ LGQDT 361_ FWVTE 366_ PEAGG 371_ LLSSR 376_ GRERR 381_ VFLFE 386_ QIIIF 391_ SEALG 396_ GGVRG 401_ GTQPG 406_ YVYKN 411_ SIKVS 416_ CLGLE 421_ GNLQG 426_ DPCRF 431_ ALTSR 436_ GPEGG 441_ IQRYV 446_ LQAAD 451_ PAISQ 456_ AWIKH 461_ VAQIL 466_ ESQRD 471_ FLNAL 476_ QSPIE 481_ YQRRE 486_ SQTNS 491_ LGRPR 496_ GPGVG 501_ SPGRI 506_ QLGDQ 511_ AQGST 516_ HTPIN 521_ GSLPS 526_ LLLSP 531_ KGEVA 536_ RALLP 541_ LDKQA 546_ LGDIP 551_ QAPHD 556_ SPPVS 561_ PTPKT 566_ PPCQA 571_RLAKL
1: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity)