Gene name: COMMD7

Uniprot entry:

Q86VX2

Protein names:

COMM domain-containing protein 7

Protein sequence:

1_MGRLH 6_ CTEDP 11_ VPEAV 16_ GGDMQ 21_ QLNQL 26_ GAQQF 31_ SALTE 36_ VLFHF 41_ LTEPK 46_ EVERF 51_ LAQLS 56_ EFATT 61_ NQISL 66_ GSLRS 71_ IVKSL 76_ LLVPN 81_ GALKK 86_ SLTAK 91_ QVQAD 96_ FITLG 101_ LSEEK 106_ ATYFS 111_ EKWKQ 116_ NAPTL 121_ ARWAI 126_ GQTLM 131_ INQLI 136_ DMEWK 141_ FGVTS 146_ GSSEL 151_ EKVGS 156_ IFLQL 161_ KLVVK 166_ KGNQT 171_ ENVYI 176_ ELTLP 181_ QFYSF 186_ LHEME 191_RVRTS

Protein annotations

Protein functions:

1: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966)