P2Y purinoceptor 8 (P2Y8)
1_MQVPN 6_ STGPD 11_ NATLQ 16_ MLRNP 21_ AIAVA 26_ LPVVY 31_ SLVAA 36_ VSIPG 41_ NLFSL 46_ WVLCR 51_ RMGPR 56_ SPSVI 61_ FMINL 66_ SVTDL 71_ MLASV 76_ LPFQI 81_ YYHCN 86_ RHHWV 91_ FGVLL 96_ CNVVT 101_ VAFYA 106_ NMYSS 111_ ILTMT 116_ CISVE 121_ RFLGV 126_ LYPLS 131_ SKRWR 136_ RRRYA 141_ VAACA 146_ GTWLL 151_ LLTAL 156_ SPLAR 161_ TDLTY 166_ PVHAL 171_ GIITC 176_ FDVLK 181_ WTMLP 186_ SVAMW 191_ AVFLF 196_ TIFIL 201_ LFLIP 206_ FVITV 211_ ACYTA 216_ TILKL 221_ LRTEE 226_ AHGRE 231_ QRRRA 236_ VGLAA 241_ VVLLA 246_ FVTCF 251_ APNNF 256_ VLLAH 261_ IVSRL 266_ FYGKS 271_ YYHVY 276_ KLTLC 281_ LSCLN 286_ NCLDP 291_ FVYYF 296_ ASREF 301_ QLRLR 306_ EYLGC 311_ RRVPR 316_ DTLDT 321_ RRESL 326_ FSART 331_ TSVRS 336_ EAGAH 341_ PEGME 346_ GATRP 351_GLQRQ
1: G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs (PubMed:25274307, PubMed:30842656, PubMed:34088745). In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed (PubMed:25274307, PubMed:30842656, PubMed:34088745). In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma (PubMed:30842656, PubMed:34088745). Contributes to GNA13-dependent pathway that suppresses GC B cell growth (PubMed:25274307)