Juxtaposed with another zinc finger protein 1 (TAK1-interacting protein 27) (Zinc finger protein 802)
1_MTGIA 6_ AASFF 11_ SNTCR 16_ FGGCG 21_ LHFPT 26_ LADLI 31_ EHIED 36_ NHIDT 41_ DPRVL 46_ EKQEL 51_ QQPTY 56_ VALSY 61_ INRFM 66_ TDAAR 71_ REQES 76_ LKKKI 81_ QPKLS 86_ LTLSS 91_ SVSRG 96_ NVSTP 101_ PRHSS 106_ GSLTP 111_ PVTPP 116_ ITPSS 121_ SFRSS 126_ TPTGS 131_ EYDEE 136_ EVDYE 141_ ESDSD 146_ ESWTT 151_ ESAIS 156_ SEAIL 161_ SSMCM 166_ NGGEE 171_ KPFAC 176_ PVPGC 181_ KKRYK 186_ NVNGI 191_ KYHAK 196_ NGHRT 201_ QIRVR 206_ KPFKC 211_ RCGKS 216_ YKTAQ 221_ GLRHH 226_ TINFH 231_ PPVSA 236_EIIRK
1: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity)