NACHT, LRR and PYD domains-containing protein 10 (Nucleotide-binding oligomerization domain protein 8)
1_MAMAK 6_ ARKPR 11_ EALLW 16_ ALSDL 21_ EENDF 26_ KKLKF 31_ YLRDM 36_ TLSEG 41_ QPPLA 46_ RGELE 51_ GLIPV 56_ DLAEL 61_ LISKY 66_ GEKEA 71_ VKVVL 76_ KGLKV 81_ MNLLE 86_ LVDQL 91_ SHICL 96_ HDYRE 101_ VYREH 106_ VRCLE 111_ EWQEA 116_ GVNGR 121_ YNQVL 126_ LVAKP 131_ SSESP 136_ ESLAC 141_ PFPEQ 146_ ELESV 151_ TVEAL 156_ FDSGE 161_ KPSLA 166_ PSLVV 171_ LQGSA 176_ GTGKT 181_ TLARK 186_ MVLDW 191_ ATGTL 196_ YPGRF 201_ DYVFY 206_ VSCKE 211_ VVLLL 216_ ESKLE 221_ QLLFW 226_ CCGDN 231_ QAPVT 236_ EILRQ 241_ PERLL 246_ FILDG 251_ FDELQ 256_ RPFEE 261_ KLKKR 266_ GLSPK 271_ ESLLH 276_ LLIRR 281_ HTLPT 286_ CSLLI 291_ TTRPL 296_ ALRNL 301_ EPLLK 306_ QARHV 311_ HILGF 316_ SEEER 321_ ARYFS 326_ SYFTD 331_ EKQAD 336_ RAFDI 341_ VQKND 346_ ILYKA 351_ CQVPG 356_ ICWVV 361_ CSWLQ 366_ GQMER 371_ GKVVL 376_ ETPRN 381_ STDIF 386_ MAYVS 391_ TFLPP 396_ DDDGG 401_ CSELS 406_ RHRVL 411_ RSLCS 416_ LAAEG 421_ IQHQR 426_ FLFEE 431_ AELRK 436_ HNLDG 441_ PRLAA 446_ FLSSN 451_ DYQLG 456_ LAIKK 461_ FYSFR 466_ HISFQ 471_ DFFHA 476_ MSYLV 481_ KEDQS 486_ RLGKE 491_ SRREV 496_ QRLLE 501_ VKEQE 506_ GNDEM 511_ TLTMQ 516_ FLLDI 521_ SKKDS 526_ FSNLE 531_ LKFCF 536_ RISPC 541_ LAQDL 546_ KHFKE 551_ QMESM 556_ KHNRT 561_ WDLEF 566_ SLYEA 571_ KIKNL 576_ VKGIQ 581_ MNNVS 586_ FKIKH 591_ SNEKK 596_ SQSQN 601_ LFSVK 606_ SSLSH 611_ GPKEE 616_ QKCPS 621_ VHGQK 626_ EGKDN 631_ IAGTQ 636_ KEAST 641_ GKGRG 646_TEETP
1: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819)