THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)
1_MERAV 6_ PLAVP 11_ LGQTE 16_ VFQAL 21_ QRLHM 26_ TIFSQ 31_ SVSPC 36_ GKFLA 41_ AGNNY 46_ GQIAI 51_ FSLSS 56_ ALSSE 61_ AKEES 66_ KKPVV 71_ TFQAH 76_ DGPVY 81_ SMVST 86_ DRHLL 91_ SAGDG 96_ EVKAW 101_ LWAEM 106_ LKKGC 111_ KELWR 116_ RQPPY 121_ RTSLE 126_ VPEIN 131_ ALLLV 136_ PKENS 141_ LILAG 146_ GDCQL 151_ HTMDL 156_ ETGTF 161_ TRVLR 166_ GHTDY 171_ IHCLA 176_ LRERS 181_ PEVLS 186_ GGEDG 191_ AVRLW 196_ DLRTA 201_ KEVQT 206_ IEVYK 211_ HEECS 216_ RPHNG 221_ RWIGC 226_ LATDS 231_ DWMVC 236_ GGGPA 241_ LTLWH 246_ LRSST 251_ PTTIF 256_ PIRAP 261_ QKHVT 266_ FYQDL 271_ ILSAG 276_ QGRCV 281_ NQWQL 286_ SGELK 291_ AQVPG 296_ SSPGL 301_ LSLSL 306_ NQQPA 311_ APECK 316_ VLTAA 321_ GNSCR 326_ VDVFT 331_ NLGYR 336_AFSLS
1: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15998806, PubMed:17190602). Plays a role in apoptosis negative control involved in brain development (PubMed:15833825, PubMed:23621916)
2: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production