Calcium-activated potassium channel subunit beta-4 (BK channel subunit beta-4) (BKbeta4) (Hbeta4) (Calcium-activated potassium channel, subfamily M subunit beta-4) (Charybdotoxin receptor subunit beta-4) (K(VCA)beta-4) (Maxi K channel subunit beta-4) (Slo-beta-4)
1_MAKLR 6_ VAYEY 11_ TEAED 16_ KSIRL 21_ GLFLI 26_ ISGVV 31_ SLFIF 36_ GFCWL 41_ SPALQ 46_ DLQAT 51_ EANCT 56_ VLSVQ 61_ QIGEV 66_ FECTF 71_ TCGAD 76_ CRGTS 81_ QYPCV 86_ QVYVN 91_ NSESN 96_ SRALL 101_ HSDEH 106_ QLLTN 111_ PKCSY 116_ IPPCK 121_ RENQK 126_ NLESV 131_ MNWQQ 136_ YWKDE 141_ IGSQP 146_ FTCYF 151_ NQHQR 156_ PDDVL 161_ LHRTH 166_ DEIVL 171_ LHCFL 176_ WPLVT 181_ FVVGV 186_ LIVVL 191_ TICAK 196_ SLAVK 201_AEAMK
1: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations