Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143)
1_MNAGP 6_ GCEPC 11_ TKRPR 16_ WGAAT 21_ TSPAA 26_ SDARS 31_ FPSRQ 36_ RRVLD 41_ PKDAH 46_ VQFRV 51_ PPSSP 56_ ACVPG 61_ RAGQH 66_ RGSAT 71_ SLVFK 76_ QKTIT 81_ SWMDT 86_ KGIKT 91_ AESES 96_ LDSKE 101_ NNNTR 106_ IESMM 111_ SSVQK 116_ DNFYQ 121_ HNVEK 126_ LENVS 131_ QLSLD 136_ KSPTE 141_ KSTQY 146_ LNQHQ 151_ TAAMC 156_ KWQNE 161_ GKHTE 166_ QLLES 171_ EPQTV 176_ TLVPE 181_ QFSNA 186_ NIDRS 191_ PQNDD 196_ HSDTD 201_ SEENR 206_ DNQQF 211_ LTTVK 216_ LANAK 221_ QTTED 226_ EQARE 231_ AKSHQ 236_ KCSKS 241_ CDPGE 246_ DCASC 251_ QQDEI 256_ DVVPE 261_ SPLSD 266_ VGSED 271_ VGTGP 276_ KNDNK 281_ LTRQE 286_ SCLGN 291_ SPPFE 296_ KESEP 301_ ESPMD 306_ VDNSK 311_ NSCQD 316_ SEADE 321_ ETSPG 326_ FDEQE 331_ DGSSS 336_ QTANK 341_ PSRFQ 346_ ARDAD 351_ IEFRK 356_ RYSTK 361_ GGEVR 366_ LHFQF 371_ EGGES 376_ RTGMN 381_ DLNAK 386_ LPGNI 391_ SSLNV 396_ ECRNS 401_ KQHGK 406_ KDSKI 411_ TDHFM 416_ RLPKA 421_ EDRRK 426_ EQWET 431_ KHQRT 436_ ERKIP 441_ KYVPP 446_ HLSPD 451_ KKWLG 456_ TPIEE 461_ MRRMP 466_ RCGIR 471_ LPLLR 476_ PSANH 481_ TVTIR 486_ VDLLR 491_ AGEVP 496_ KPFPT 501_ HYKDL 506_ WDNKH 511_ VKMPC 516_ SEQNL 521_ YPVED 526_ ENGER 531_ TAGSR 536_ WELIQ 541_ TALLN 546_ KFTRP 551_ QNLKD 556_ AILKY 561_ NVAYS 566_ KKWDF 571_ TALID 576_ FWDKV 581_ LEEAE 586_ AQHLY 591_ QSILP 596_ DMVKI 601_ ALCLP 606_ NICTQ 611_ PIPLL 616_ KQKMN 621_ HSITM 626_ SQEQI 631_ ASLLA 636_ NAFFC 641_ TFPRR 646_ NAKMK 651_ SEYSS 656_ YPDIN 661_ FNRLF 666_ EGRSS 671_ RKPEK 676_ LKTLF 681_ CYFRR 686_ VTEKK 691_ PTGLV 696_ TFTRQ 701_ SLEDF 706_ PEWER 711_ CEKPL 716_ TRLHV 721_ TYEGT 726_ IEENG 731_ QGMLQ 736_ VDFAN 741_ RFVGG 746_ GVTSA 751_ GLVQE 756_ EIRFL 761_ INPEL 766_ IISRL 771_ FTEVL 776_ DHNEC 781_ LIITG 786_ TEQYS 791_ EYTGY 796_ AETYR 801_ WSRSH 806_ EDGSE 811_ RDDWQ 816_ RRCTE 821_ IVAID 826_ ALHFR 831_ RYLDQ 836_ FVPEK 841_ MRREL 846_ NKAYC 851_ GFLRP 856_ GVSSE 861_ NLSAV 866_ ATGNW 871_ GCGAF 876_ GGDAR 881_ LKALI 886_ QILAA 891_ AAAER 896_ DVVYF 901_ TFGDS 906_ ELMRD 911_ IYSMH 916_ IFLTE 921_ RKLTV 926_ GDVYK 931_ LLLRY 936_ YNEEC 941_ RNCST 946_ PGPDI 951_ KLYPF 956_ IYHAV 961_ ESCAE 966_ TADHS 971_GQRTG
1: Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257)