Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA)
1_MVAVL 6_ GGRGV 11_ LRLRL 16_ LLSAL 21_ KPGIH 26_ VPRAG 31_ PAAAF 36_ GTSVT 41_ SAKVA 46_ VNGVQ 51_ LHYQQ 56_ TGEGD 61_ HAVLL 66_ LPGML 71_ GSGET 76_ DFGPQ 81_ LKNLN 86_ KKLFT 91_ VVAWD 96_ PRGYG 101_ HSRPP 106_ DRDFP 111_ ADFFE 116_ RDAKD 121_ AVDLM 126_ KALKF 131_ KKVSL 136_ LGWSD 141_ GGITA 146_ LIAAA 151_ KYPSY 156_ IHKMV 161_ IWGAN 166_ AYVTD 171_ EDSMI 176_ YEGIR 181_ DVSKW 186_ SERTR 191_ KPLEA 196_ LYGYD 201_ YFART 206_ CEKWV 211_ DGIRQ 216_ FKHLP 221_ DGNIC 226_ RHLLP 231_ RVQCP 236_ ALIVH 241_ GEKDP 246_ LVPRF 251_ HADFI 256_ HKHVK 261_ GSRLH 266_ LMPEG 271_ KHNLH 276_ LRFAD 281_ EFNKL 286_AEDFL
1: Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (PubMed:12732646, PubMed:15832508, PubMed:18256025, PubMed:25333274, PubMed:32196348). Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo (PubMed:25333274). Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir) (PubMed:15832508, PubMed:18256025)