Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2)
1_MARLA 6_ DYFIV 11_ VGYDH 16_ EKPGS 21_ GEGLG 26_ KIIQR 31_ FPQKD 36_ WDDTP 41_ FPQGI 46_ ELFCQ 51_ PGGWQ 56_ LSRER 61_ KQPTF 66_ FVVVL 71_ TDIDS 76_ DRHYC 81_ SCLTF 86_ YEAEI 91_ NLQGT 96_ KKEEI 101_ EGEAK 106_ VSGLI 111_ QPAEV 116_ FAPKS 121_ LVLVS 126_ RLYYP 131_ EIFRA 136_ CLGLI 141_ YTVYV 146_ DSLNV 151_ SLESL 156_ IANLC 161_ ACLVP 166_ AAGGS 171_ QKLFS 176_ LGAGD 181_ RQLIQ 186_ TPLHD 191_ SLPIT 196_ GTSVA 201_ LLFQQ 206_ LGIQN 211_ VLSLF 216_ CAVLT 221_ ENKVL 226_ FHSAS 231_ FQRLS 236_ DACRA 241_ LESLM 246_ FPLKY 251_ SYPYI 256_ PILPA 261_ QLLEV 266_ LSSPT 271_ PFIIG 276_ VHSVF 281_ KTDVH 286_ ELLDV 291_ IIADL 296_ DGGTI 301_ KIPEC 306_ IHLSS 311_ LPEPL 316_ LHQTQ 321_ SALSL 326_ ILHPD 331_ LEVAD 336_ HAFPP 341_ PRTAL 346_ SHSKM 351_ LDKEV 356_ RAVFL 361_ RLFAQ 366_ LFQGY 371_ RSCLQ 376_ LIRIH 381_ AEPVI 386_ HFHKT 391_ AFLGQ 396_ RGLVE 401_ NDFLT 406_ KVLSG 411_ MAFAG 416_ FVSER 421_ GPPYR 426_ SCDLF 431_ DELVA 436_ FEVER 441_ IKVEE 446_ NNPVK 451_ MIKHV 456_ RELAE 461_ QLFKN 466_ ENPNP 471_ HMAFQ 476_ KVPRP 481_ TEGSH 486_ LRVHI 491_ LPFPE 496_ INEAR 501_ VQELI 506_ QENVA 511_ KNQNA 516_ PPATR 521_ IEKKC 526_ VVPAG 531_ PPVVS 536_ IMDKV 541_ TTVFN 546_ SAQRL 551_ EVVRN 556_ CISFI 561_ FENKI 566_ LETEK 571_ TLPAA 576_ LRALK 581_ GKAAR 586_ QCLTD 591_ ELGLH 596_ VQQNR 601_ AILDH 606_ QQFDY 611_ IIRMM 616_ NCTLQ 621_ DCSSL 626_ EEYNI 631_ AAALL 636_ PLTSA 641_ FYRKL 646_ APGVS 651_ QFAYT 656_ CVQDH 661_ PIWTN 666_ QQFWE 671_ TTFYN 676_ AVQEQ 681_ VRSLY 686_ LSAKE 691_ DNHAP 696_ HLKQK 701_ DKLPD 706_ DHYQE 711_ KTAMD 716_ LAAEQ 721_ LRLWP 726_ TLSKS 731_ TQQEL 736_ VQHEE 741_ STVFS 746_ QAIHF 751_ ANLMV 756_ NLLVP 761_ LDTSK 766_ NKLLR 771_ TSAPG 776_ DWESG 781_ SNSIV 786_ TNSIA 791_ GSVAE 796_ SYDTE 801_ SGFED 806_ SENTD 811_ IANSV 816_ VRFIT 821_ RFIDK 826_ VCTES 831_ GVTQD 836_ HIKSL 841_ HCMIP 846_ GIVAM 851_ HIETL 856_ EAVHR 861_ ESRRL 866_ PPIQK 871_ PKILR 876_ PALLP 881_ GEEIV 886_ CEGLR 891_ VLLDP 896_ DGREE 901_ ATGGL 906_ LGGPQ 911_ LLPAE 916_ GALFL 921_ TTYRI 926_ LFRGT 931_ PHDQL 936_ VGEQT 941_ VVRSF 946_ PIASI 951_ TKEKK 956_ ITMQN 961_ QLQQN 966_ MQEGL 971_ QITSA 976_ SFQLI 981_ KVAFD 986_ EEVSP 991_ EVVEI 996_ FKKQL 1001_ MKFRY 1006_ PQSIF 1011_ STFAF 1016_ AAGQT 1021_ TPQII 1026_ LPKQK 1031_ EKNTS 1036_ FRTFS 1041_ KTIVK 1046_ GAKRA 1051_ GKMTI 1056_ GRQYL 1061_ LKKKT 1066_ GTIVE 1071_ ERVNR 1076_ PGWNE 1081_ DDDVS 1086_ VSDES 1091_ ELPTS 1096_ TTLKA 1101_ SEKST 1106_ MEQLV 1111_ EKACF 1116_ RDYQR 1121_ LGLGT 1126_ ISGSS 1131_ SRSRP 1136_ EYFRI 1141_ TASNR 1146_ MYSLC 1151_ RSYPG 1156_ LLVVP 1161_ QAVQD 1166_ SSLPR 1171_ VARCY 1176_ RHNRL 1181_ PVVCW 1186_ KNSRS 1191_ GTLLL 1196_ RSGGF 1201_ HGKGV 1206_ VGLFK 1211_ SQNSP 1216_ QAAPT 1221_ SSLES 1226_ SSSIE 1231_ QEKYL 1236_ QALLN 1241_ AVSVH 1246_ QKLRG 1251_ NSTLT 1256_ VRPAF 1261_ ALSPG 1266_ VWASL 1271_ RSSTR 1276_ LISSP 1281_ TSFID 1286_ VGARL 1291_ AGKDH 1296_ SASFS 1301_ NSSYL 1306_ QNQLL 1311_ KRQAA 1316_ LYIFG 1321_ EKSQL 1326_ RNFKV 1331_ EFALN 1336_ CEFVP 1341_ VEFHE 1346_ IRQVK 1351_ ASFKK 1356_ LMRAC 1361_ IPSTI 1366_ PTDSE 1371_ VTFLK 1376_ ALGDS 1381_ EWFPQ 1386_ LHRIM 1391_ QLAVV 1396_ VSEVL 1401_ ENGSS 1406_ VLVCL 1411_ EEGWD 1416_ ITAQV 1421_ TSLVQ 1426_ LLSDP 1431_ FYRTL 1436_ EGFQM 1441_ LVEKE 1446_ WLSFG 1451_ HKFSQ 1456_ RSSLT 1461_ LNCQG 1466_ SGFAP 1471_ VFLQF 1476_ LDCVH 1481_ QVHNQ 1486_ YPTEF 1491_ EFNLY 1496_ YLKFL 1501_ AFHYV 1506_ SNRFK 1511_ TFLLD 1516_ SDYER 1521_ LEHGT 1526_ LFDDK 1531_ GEKHA 1536_ KKGVC 1541_ IWECI 1546_ DRMHK 1551_ RSPIF 1556_ FNYLY 1561_ SPLEI 1566_ EALKP 1571_ NVNVS 1576_ SLKKW 1581_ DYYIE 1586_ ETLST 1591_ GPSYD 1596_ WMMLT 1601_ PKHFP 1606_ SEDSD 1611_ LAGEA 1616_ GPRSQ 1621_ RRTVW 1626_ PCYDD 1631_ VSCTQ 1636_ PDALT 1641_ SLFSE 1646_ IEKLE 1651_ HKLNQ 1656_ APEKW 1661_ QQLWE 1666_ RVTVD 1671_ LKEEP 1676_ RTDRS 1681_ QRHLS 1686_ RSPGI 1691_ VSTNL 1696_ PSYQK 1701_ RSLLH 1706_ LPDSS 1711_ MGEEQ 1716_ NSSIS 1721_ PSNGV 1726_ ERRAA 1731_ TLYSQ 1736_ YTSKN 1741_ DENRS 1746_ FEGTL 1751_ YKRGA 1756_ LLKGW 1761_ KPRWF 1766_ VLDVT 1771_ KHQLR 1776_ YYDSG 1781_ EDTSC 1786_ KGHID 1791_ LAEVE 1796_ MVIPA 1801_ GPSMG 1806_ APKHT 1811_ SDKAF 1816_ FDLKT 1821_ SKRVY 1826_ NFCAQ 1831_ DGQSA 1836_ QQWMD 1841_KIQSC
1: Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity)