Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) (Amplified in liver cancer protein 1)
1_MERAG 6_ ATSRG 11_ GQAPG 16_ FLLRL 21_ HTEGR 26_ AEAAR 31_ VQEQD 36_ LRQWG 41_ LTGIH 46_ LRSYQ 51_ LEGVN 56_ WLAQR 61_ FHCQN 66_ GCILG 71_ DEMGL 76_ GKTCQ 81_ TIALF 86_ IYLAG 91_ RLNDE 96_ GPFLI 101_ LCPLS 106_ VLSNW 111_ KEEMQ 116_ RFAPG 121_ LSCVT 126_ YAGDK 131_ EERAC 136_ LQQDL 141_ KQESR 146_ FHVLL 151_ TTYEI 156_ CLKDA 161_ SFLKS 166_ FPWSV 171_ LVVDE 176_ AHRLK 181_ NQSSL 186_ LHKTL 191_ SEFSV 196_ VFSLL 201_ LTGTP 206_ IQNSL 211_ QELYS 216_ LLSFV 221_ EPDLF 226_ SKEEV 231_ GDFIQ 236_ RYQDI 241_ EKESE 246_ SASEL 251_ HKLLQ 256_ PFLLR 261_ RVKAE 266_ VATEL 271_ PKKTE 276_ VVIYH 281_ GMSAL 286_ QKKYY 291_ KAILM 296_ KDLDA 301_ FENET 306_ AKKVK 311_ LQNIL 316_ SQLRK 321_ CVDHP 326_ YLFDG 331_ VEPEP 336_ FEVGD 341_ HLTEA 346_ SGKLH 351_ LLDKL 356_ LAFLY 361_ SGGHR 366_ VLLFS 371_ QMTQM 376_ LDILQ 381_ DYMDY 386_ RGYSY 391_ ERVDG 396_ SVRGE 401_ ERHLA 406_ IKNFG 411_ QQPIF 416_ VFLLS 421_ TRAGG 426_ VGMNL 431_ TAADT 436_ VIFVD 441_ SDFNP 446_ QNDLQ 451_ AAARA 456_ HRIGQ 461_ NKSVK 466_ VIRLI 471_ GRDTV 476_ EEIVY 481_ RKAAS 486_ KLQLT 491_ NMIIE 496_ GGHFT 501_ LGAQK 506_ PAADA 511_ DLQLS 516_ EILKF 521_ GLDKL 526_ LASEG 531_ STMDE 536_ IDLES 541_ ILGET 546_ KDGQW 551_ VSDAL 556_ PAAEG 561_ GSRDQ 566_ EEGKN 571_ HMYLF 576_ EGKDY 581_ SKEPS 586_ KEDRK 591_ SFEQL 596_ VNLQK 601_ TLLEK 606_ ASQEG 611_ RSLRN 616_ KGSVL 621_ IPGLV 626_ EGSTK 631_ RKRVL 636_ SPEEL 641_ EDRQK 646_ KRQEA 651_ AAKRR 656_ RLIEE 661_ KKRQK 666_ EEAEH 671_ KKKMA 676_ WWESN 681_ NYQSF 686_ CLPSE 691_ ESEPE 696_ DLENG 701_ EESSA 706_ ELDYQ 711_ DPDAT 716_ SLKYV 721_ SGDVT 726_ HPQAG 731_ AEDAL 736_ IVHCV 741_ DDSGH 746_ WGRGG 751_ LFTAL 756_ EKRSA 761_ EPRKI 766_ YELAG 771_ KMKDL 776_ SLGGV 781_ LLFPV 786_ DDKES 791_ RNKGQ 796_ DLLAL 801_ IVAQH 806_ RDRSN 811_ VLSGI 816_ KMAAL 821_ EEGLK 826_ KIFLA 831_ AKKKK 836_ ASVHL 841_ PRIGH 846_ ATKGF 851_ NWYGT 856_ ERLIR 861_ KHLAA 866_ RGIPT 871_ YIYYF 876_ PRSKS 881_ AVLHS 886_ QSSSS 891_SSRQL
1: ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34210977, PubMed:34486521, PubMed:34874266). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888)