Coiled-coil domain-containing protein 25
1_MVFYF 6_ TSSSV 11_ NSSAY 16_ TIYMG 21_ KDKYE 26_ NEDLI 31_ KHGWP 36_ EDIWF 41_ HVDKL 46_ SSAHV 51_ YLRLH 56_ KGENI 61_ EDIPK 66_ EVLMD 71_ CAHLV 76_ KANSI 81_ QGCKM 86_ NNVNV 91_ VYTPW 96_ SNLKK 101_ TADMD 106_ VGQIG 111_ FHRQK 116_ DVKIV 121_ TVEKK 126_ VNEIL 131_ NRLEK 136_ TKVER 141_ FPDLA 146_ AEKEC 151_ RDREE 156_ RNEKK 161_ AQIQE 166_ MKKRE 171_ KEEMK 176_ KKREM 181_ DELRS 186_ YSSLM 191_ KVENM 196_ SSNQD 201_GNDSD
1: Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174)