Transmembrane protease serine 12 (EC 3.4.21.-)
1_MRLGL 6_ LSVAL 11_ LFVGS 16_ SHLYS 21_ DHYSP 26_ SGRHR 31_ LGPSP 36_ EPAAS 41_ SQQAE 46_ AVRKR 51_ LRRRR 56_ EGGAH 61_ AEDCG 66_ TAPLK 71_ DVLQG 76_ SRIIG 81_ GTEAQ 86_ AGAWP 91_ WVVSL 96_ QIKYG 101_ RVLVH 106_ VCGGT 111_ LVRER 116_ WVLTA 121_ AHCTK 126_ DASDP 131_ LMWTA 136_ VIGTN 141_ NIHGR 146_ YPHTK 151_ KIKIK 156_ AIIIH 161_ PNFIL 166_ ESYVN 171_ DIALF 176_ HLKKA 181_ VRYND 186_ YIQPI 191_ CLPFD 196_ VFQIL 201_ DGNTK 206_ CFISG 211_ WGRTK 216_ EEGNA 221_ TNILQ 226_ DAEVH 231_ YISRE 236_ MCNSE 241_ RSYGG 246_ IIPNT 251_ SFCAG 256_ DEDGA 261_ FDTCR 266_ GDSGG 271_ PLMCY 276_ LPEYK 281_ RFFVM 286_ GITSY 291_ GHGCG 296_ RRGFP 301_ GVYIG 306_ PSFYQ 311_ KWLTE 316_ HFFHA 321_ STQGI 326_ LTINI 331_ LRGQI 336_ LIALC 341_FVILL
1: Required for male fertility (By similarity). Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis (By similarity). Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm (By similarity). Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation (By similarity)