E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69)
1_MEVST 6_ NPSSN 11_ IDPGD 16_ YVEMN 21_ DSITH 26_ LPSKV 31_ VIQDI 36_ TMELH 41_ CPLCN 46_ DWFRD 51_ PLMLS 56_ CGHNF 61_ CEACI 66_ QDFWR 71_ LQAKE 76_ TFCPE 81_ CKMLC 86_ QYNNC 91_ TFNPV 96_ LDKLV 101_ EKIKK 106_ LPLLK 111_ GHPQC 116_ PEHGE 121_ NLKLF 126_ SKPDG 131_ KLICF 136_ QCKDA 141_ RLSVG 146_ QSKEF 151_ LQISD 156_ AVHFF 161_ TEELA 166_ IQQGQ 171_ LETTL 176_ KELQT 181_ LRNMQ 186_ KEAIA 191_ AHKEN 196_ KLHLQ 201_ QHVSM 206_ EFLKL 211_ HQFLH 216_ SKEKD 221_ ILTEL 226_ REEGK 231_ ALNEE 236_ MELNL 241_ SQLQE 246_ QCLLA 251_ KDMLV 256_ SIQAK 261_ TEQQN 266_ SFDFL 271_ KDITT 276_ LLHSL 281_ EQGMK 286_ VLATR 291_ ELISR 296_ KLNLG 301_ QYKGP 306_ IQYMV 311_ WREMQ 316_ DTLCP 321_ GLSPL 326_ TLDPK 331_ TAHPN 336_ LVLSK 341_ SQTSV 346_ WHGDI 351_ KKIMP 356_ DDPER 361_ FDSSV 366_ AVLGS 371_ RGFTS 376_ GKWYW 381_ EVEVA 386_ KKTKW 391_ TVGVV 396_ RESII 401_ RKGSC 406_ PLTPE 411_ QGFWL 416_ LRLRN 421_ QTDLK 426_ ALDLP 431_ SFSLT 436_ LTNNL 441_ DKVGI 446_ YLDYE 451_ GGQLS 456_ FYNAK 461_ TMTHI 466_ YTFSN 471_ TFMEK 476_ LYPYF 481_ CPCLN 486_ DGGEN 491_KEPLH
1: E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Also plays a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411)